Detailed information of TA system TA231812

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1174800..1175499
• Replicon: chromosome
• Accession: NZ_CP090754
• Organism: Burkholderia multivorans strain 2010Ycf41

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: L0Z40_RS20845
• Protein ID: WP_105751843.1
• Coordinates: 1175203..1175499 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9BI88
• Locus tag: L0Z40_RS20840
• Protein ID: WP_006403504.1
• Coordinates: 1174800..1175201 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z40_RS20820 (L0Z40_20820)	1170502..1171854	-	1353	WP_006409061.1	LLM class flavin-dependent oxidoreductase	-
L0Z40_RS20825 (L0Z40_20825)	1171851..1172912	-	1062	WP_105751841.1	LLM class flavin-dependent oxidoreductase	-
L0Z40_RS20830 (L0Z40_20830)	1172944..1173885	-	942	WP_035487669.1	ABC transporter substrate-binding protein	-
L0Z40_RS20835 (L0Z40_20835)	1173951..1174511	-	561	WP_105751842.1	GNAT family N-acetyltransferase	-
L0Z40_RS20840 (L0Z40_20840)	1174800..1175201	-	402	WP_006403504.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
L0Z40_RS20845 (L0Z40_20845)	1175203..1175499	-	297	WP_105751843.1	type II toxin-antitoxin system MqsR family toxin	Toxin
L0Z40_RS20850 (L0Z40_20850)	1175619..1176653	-	1035	WP_069221065.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
L0Z40_RS20855 (L0Z40_20855)	1176754..1177026	-	273	WP_006403506.1	hypothetical protein	-
L0Z40_RS20860 (L0Z40_20860)	1177233..1178774	-	1542	WP_167338149.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11128.07 Da
• Isoelectric Point: 9.1122

>T231812 WP_105751843.1 NZ_CP090754:c1175499-1175203 [Burkholderia multivorans]
MEKRTAHCKLPRVKALIEAGKVRLTASAVIGARLMGFTEAEAIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T231812 NZ_CP126955:111418-111591 [Escherichia coli O78:H4]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACTTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT231812 WP_006403504.1 NZ_CP090754:c1175201-1174800 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT231812 NZ_CP126955:111094-111390 [Escherichia coli O78:H4]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: B9BI88