Detailed information of TA system TA231782

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1150728..1151427
• Replicon: chromosome
• Accession: NZ_CP090742
• Organism: Burkholderia multivorans strain 2010Ycf635

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: L0Z21_RS23505
• Protein ID: WP_053298526.1
• Coordinates: 1151131..1151427 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9BI88
• Locus tag: L0Z21_RS23500
• Protein ID: WP_006403504.1
• Coordinates: 1150728..1151129 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z21_RS23480 (L0Z21_23480)	1146431..1147783	-	1353	WP_006409061.1	LLM class flavin-dependent oxidoreductase	-
L0Z21_RS23485 (L0Z21_23485)	1147780..1148841	-	1062	WP_065496516.1	LLM class flavin-dependent oxidoreductase	-
L0Z21_RS23490 (L0Z21_23490)	1148873..1149814	-	942	WP_069221063.1	ABC transporter substrate-binding protein	-
L0Z21_RS23495 (L0Z21_23495)	1149879..1150439	-	561	WP_069221064.1	GNAT family N-acetyltransferase	-
L0Z21_RS23500 (L0Z21_23500)	1150728..1151129	-	402	WP_006403504.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
L0Z21_RS23505 (L0Z21_23505)	1151131..1151427	-	297	WP_053298526.1	type II toxin-antitoxin system MqsR family toxin	Toxin
L0Z21_RS23510 (L0Z21_23510)	1151547..1152581	-	1035	WP_069221065.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
L0Z21_RS23515 (L0Z21_23515)	1152682..1152954	-	273	WP_006403506.1	hypothetical protein	-
L0Z21_RS23520 (L0Z21_23520)	1153160..1154701	-	1542	WP_172820327.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11173.06 Da
• Isoelectric Point: 9.1122

>T231782 WP_053298526.1 NZ_CP090742:c1151427-1151131 [Burkholderia multivorans]
MEKRTAHCKLPRVKALIEAGKVRLTASAVIGARQMGFTEAETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T231782 NZ_CP126952:c344907-344632 [Escherichia coli O78:H4]
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTT
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT231782 WP_006403504.1 NZ_CP090742:c1151129-1150728 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT231782 NZ_CP126952:c344635-344276 [Escherichia coli O78:H4]
ATGATCAAACTGAAGACACCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTACTAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: B9BI88