Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1682524..1683223 Replicon chromosome
Accession NZ_CP090738
Organism Burkholderia cepacia strain 2011Ycf427V

Toxin (Protein)


Gene name mqsR Uniprot ID U2G672
Locus tag L0Z22_RS24550 Protein ID WP_021158759.1
Coordinates 1682927..1683223 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A365QRC5
Locus tag L0Z22_RS24545 Protein ID WP_059861535.1
Coordinates 1682524..1682925 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z22_RS24525 (L0Z22_24525) 1678169..1679521 - 1353 WP_059492206.1 LLM class flavin-dependent oxidoreductase -
L0Z22_RS24530 (L0Z22_24530) 1679529..1680578 - 1050 WP_021158755.1 LLM class flavin-dependent oxidoreductase -
L0Z22_RS24535 (L0Z22_24535) 1680642..1681589 - 948 WP_021158756.1 ABC transporter substrate-binding protein -
L0Z22_RS24540 (L0Z22_24540) 1681646..1682206 - 561 WP_027791642.1 GNAT family N-acetyltransferase -
L0Z22_RS24545 (L0Z22_24545) 1682524..1682925 - 402 WP_059861535.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
L0Z22_RS24550 (L0Z22_24550) 1682927..1683223 - 297 WP_021158759.1 type II toxin-antitoxin system MqsR family toxin Toxin
L0Z22_RS24555 (L0Z22_24555) 1683327..1684367 - 1041 WP_027791639.1 succinylglutamate desuccinylase/aspartoacylase family protein -
L0Z22_RS24560 (L0Z22_24560) 1684610..1684885 - 276 WP_021158762.1 hypothetical protein -
L0Z22_RS24565 (L0Z22_24565) 1685129..1686679 - 1551 WP_176130484.1 sensor domain-containing diguanylate cyclase -
L0Z22_RS24570 (L0Z22_24570) 1686678..1687052 + 375 WP_175891902.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA

(3-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11193.01 Da        Isoelectric Point: 8.0535

>T231770 WP_021158759.1 NZ_CP090738:c1683223-1682927 [Burkholderia cepacia]
MEKRRPHCKLSLVKALVESGQVRLTASAVLGARQLGFTEREALDVVMSLTDLDFHKSMTTYADHTIWQDVYRPLTVRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T231770 NZ_CP126948:3200863-3201249 [Escherichia coli O78:H4]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14572.81 Da        Isoelectric Point: 8.4869

>AT231770 WP_059861535.1 NZ_CP090738:c1682925-1682524 [Burkholderia cepacia]
MKCPACGAAKLVHDTRDIPYTYKGRSTVVRAITGEFCPACGESVLDLDEATRLGEAISEFNKQVNATIVDPNYIAKVRKK
LRLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Download         Length: 402 bp

>AT231770 NZ_CP126948:3201239-3201568 [Escherichia coli O78:H4]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2G672

Antitoxin

Source ID Structure
AlphaFold DB A0A365QRC5

References