Detailed information of TA system TA231759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1125838..1126537
• Replicon: chromosome
• Accession: NZ_CP090735
• Organism: Burkholderia multivorans strain 2011Ycf521III

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: L0Z43_RS23235
• Protein ID: WP_053298526.1
• Coordinates: 1126241..1126537 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9BI88
• Locus tag: L0Z43_RS23230
• Protein ID: WP_006403504.1
• Coordinates: 1125838..1126239 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z43_RS23210 (L0Z43_23210)	1121541..1122893	-	1353	WP_006409061.1	LLM class flavin-dependent oxidoreductase	-
L0Z43_RS23215 (L0Z43_23215)	1122890..1123951	-	1062	WP_065496516.1	LLM class flavin-dependent oxidoreductase	-
L0Z43_RS23220 (L0Z43_23220)	1123983..1124924	-	942	WP_069221063.1	ABC transporter substrate-binding protein	-
L0Z43_RS23225 (L0Z43_23225)	1124989..1125549	-	561	WP_069221064.1	GNAT family N-acetyltransferase	-
L0Z43_RS23230 (L0Z43_23230)	1125838..1126239	-	402	WP_006403504.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
L0Z43_RS23235 (L0Z43_23235)	1126241..1126537	-	297	WP_053298526.1	type II toxin-antitoxin system MqsR family toxin	Toxin
L0Z43_RS23240 (L0Z43_23240)	1126657..1127691	-	1035	WP_069221065.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
L0Z43_RS23245 (L0Z43_23245)	1127792..1128064	-	273	WP_006403506.1	hypothetical protein	-
L0Z43_RS23250 (L0Z43_23250)	1128270..1129811	-	1542	WP_172820327.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11173.06 Da
• Isoelectric Point: 9.1122

>T231759 WP_053298526.1 NZ_CP090735:c1126537-1126241 [Burkholderia multivorans]
MEKRTAHCKLPRVKALIEAGKVRLTASAVIGARQMGFTEAETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T231759 NZ_CP126948:c792686-792312 [Escherichia coli O78:H4]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT231759 WP_006403504.1 NZ_CP090735:c1126239-1125838 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT231759 NZ_CP126948:c793144-792776 [Escherichia coli O78:H4]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: B9BI88