Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 1693831..1694530 | Replicon | chromosome |
| Accession | NZ_CP090732 | ||
| Organism | Burkholderia cepacia strain 2011Ycf793I | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | U2G672 |
| Locus tag | L0Z05_RS30680 | Protein ID | WP_021158759.1 |
| Coordinates | 1694234..1694530 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | A0A365QRC5 |
| Locus tag | L0Z05_RS30675 | Protein ID | WP_059861535.1 |
| Coordinates | 1693831..1694232 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Z05_RS30655 (L0Z05_30655) | 1689476..1690828 | - | 1353 | WP_059492206.1 | LLM class flavin-dependent oxidoreductase | - |
| L0Z05_RS30660 (L0Z05_30660) | 1690836..1691885 | - | 1050 | WP_021158755.1 | LLM class flavin-dependent oxidoreductase | - |
| L0Z05_RS30665 (L0Z05_30665) | 1691949..1692896 | - | 948 | WP_021158756.1 | ABC transporter substrate-binding protein | - |
| L0Z05_RS30670 (L0Z05_30670) | 1692953..1693513 | - | 561 | WP_027791642.1 | GNAT family N-acetyltransferase | - |
| L0Z05_RS30675 (L0Z05_30675) | 1693831..1694232 | - | 402 | WP_059861535.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
| L0Z05_RS30680 (L0Z05_30680) | 1694234..1694530 | - | 297 | WP_021158759.1 | type II toxin-antitoxin system MqsR family toxin | Toxin |
| L0Z05_RS30685 (L0Z05_30685) | 1694634..1695674 | - | 1041 | WP_027791639.1 | succinylglutamate desuccinylase/aspartoacylase family protein | - |
| L0Z05_RS30690 (L0Z05_30690) | 1695917..1696192 | - | 276 | WP_021158762.1 | hypothetical protein | - |
| L0Z05_RS30695 (L0Z05_30695) | 1696436..1697986 | - | 1551 | WP_176130484.1 | sensor domain-containing diguanylate cyclase | - |
| L0Z05_RS30700 (L0Z05_30700) | 1697985..1698359 | + | 375 | WP_175891902.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11193.01 Da Isoelectric Point: 8.0535
>T231747 WP_021158759.1 NZ_CP090732:c1694530-1694234 [Burkholderia cepacia]
MEKRRPHCKLSLVKALVESGQVRLTASAVLGARQLGFTEREALDVVMSLTDLDFHKSMTTYADHTIWQDVYRPLTVRGDV
YLKLTVIDDVLIVSFKER
MEKRRPHCKLSLVKALVESGQVRLTASAVLGARQLGFTEREALDVVMSLTDLDFHKSMTTYADHTIWQDVYRPLTVRGDV
YLKLTVIDDVLIVSFKER
Download Length: 297 bp
>T231747 NZ_CP126946:5101715-5102101 [Escherichia coli O78:H51]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14572.81 Da Isoelectric Point: 8.4869
>AT231747 WP_059861535.1 NZ_CP090732:c1694232-1693831 [Burkholderia cepacia]
MKCPACGAAKLVHDTRDIPYTYKGRSTVVRAITGEFCPACGESVLDLDEATRLGEAISEFNKQVNATIVDPNYIAKVRKK
LRLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA
MKCPACGAAKLVHDTRDIPYTYKGRSTVVRAITGEFCPACGESVLDLDEATRLGEAISEFNKQVNATIVDPNYIAKVRKK
LRLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA
Download Length: 402 bp
>AT231747 NZ_CP126946:5101176-5101685 [Escherichia coli O78:H51]
ATGGCATATCTGAAATTGATGAAGTTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAATTGAGTCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATT
TGATCTCGCAAATATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA
ATGGCATATCTGAAATTGATGAAGTTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAATTGAGTCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATT
TGATCTCGCAAATATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U2G672 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A365QRC5 |