Detailed information of TA system TA231725

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1253078..1253777
• Replicon: chromosome
• Accession: NZ_CP090725
• Organism: Burkholderia multivorans strain 2014Y70518672I

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: L0Z29_RS21425
• Protein ID: WP_105751843.1
• Coordinates: 1253078..1253374 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9BI88
• Locus tag: L0Z29_RS21430
• Protein ID: WP_006403504.1
• Coordinates: 1253376..1253777 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z29_RS21410 (L0Z29_21410)	1249803..1251344	+	1542	WP_167338149.1	sensor domain-containing diguanylate cyclase	-
L0Z29_RS21415 (L0Z29_21415)	1251551..1251823	+	273	WP_006403506.1	hypothetical protein	-
L0Z29_RS21420 (L0Z29_21420)	1251924..1252958	+	1035	WP_069221065.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
L0Z29_RS21425 (L0Z29_21425)	1253078..1253374	+	297	WP_105751843.1	type II toxin-antitoxin system MqsR family toxin	Toxin
L0Z29_RS21430 (L0Z29_21430)	1253376..1253777	+	402	WP_006403504.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
L0Z29_RS21435 (L0Z29_21435)	1254066..1254626	+	561	WP_105751842.1	GNAT family N-acetyltransferase	-
L0Z29_RS21440 (L0Z29_21440)	1254692..1255633	+	942	WP_035487669.1	ABC transporter substrate-binding protein	-
L0Z29_RS21445 (L0Z29_21445)	1255665..1256726	+	1062	WP_105751841.1	LLM class flavin-dependent oxidoreductase	-
L0Z29_RS21450 (L0Z29_21450)	1256723..1258075	+	1353	WP_006409061.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11128.07 Da
• Isoelectric Point: 9.1122

>T231725 WP_105751843.1 NZ_CP090725:1253078-1253374 [Burkholderia multivorans]
MEKRTAHCKLPRVKALIEAGKVRLTASAVIGARLMGFTEAEAIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T231725 NZ_CP126946:261271-261621 [Escherichia coli O78:H51]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT231725 WP_006403504.1 NZ_CP090725:1253376-1253777 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT231725 NZ_CP126946:261026-261277 [Escherichia coli O78:H51]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Antitoxin

• AlphaFold DB: B9BI88