Detailed information of TA system TA231700

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1220871..1221570
• Replicon: chromosome
• Accession: NZ_CP090715
• Organism: Burkholderia multivorans strain 2015Y70629342III

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: L0Z12_RS22355
• Protein ID: WP_105751843.1
• Coordinates: 1221274..1221570 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9BI88
• Locus tag: L0Z12_RS22350
• Protein ID: WP_006403504.1
• Coordinates: 1220871..1221272 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z12_RS22330 (L0Z12_22330)	1216573..1217925	-	1353	WP_006409061.1	LLM class flavin-dependent oxidoreductase	-
L0Z12_RS22335 (L0Z12_22335)	1217922..1218983	-	1062	WP_105751841.1	LLM class flavin-dependent oxidoreductase	-
L0Z12_RS22340 (L0Z12_22340)	1219015..1219956	-	942	WP_035487669.1	ABC transporter substrate-binding protein	-
L0Z12_RS22345 (L0Z12_22345)	1220022..1220582	-	561	WP_105751842.1	GNAT family N-acetyltransferase	-
L0Z12_RS22350 (L0Z12_22350)	1220871..1221272	-	402	WP_006403504.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
L0Z12_RS22355 (L0Z12_22355)	1221274..1221570	-	297	WP_105751843.1	type II toxin-antitoxin system MqsR family toxin	Toxin
L0Z12_RS22360 (L0Z12_22360)	1221690..1222724	-	1035	WP_069221065.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
L0Z12_RS22365 (L0Z12_22365)	1222825..1223097	-	273	WP_006403506.1	hypothetical protein	-
L0Z12_RS22370 (L0Z12_22370)	1223304..1224845	-	1542	WP_167338149.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	pmlI/bspI1 / pmlR/bspR1	933057..1403904	470847

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11128.07 Da
• Isoelectric Point: 9.1122

>T231700 WP_105751843.1 NZ_CP090715:c1221570-1221274 [Burkholderia multivorans]
MEKRTAHCKLPRVKALIEAGKVRLTASAVIGARLMGFTEAEAIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T231700 NZ_CP126944:1024594-1025001 [Escherichia coli O1:K1:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT231700 WP_006403504.1 NZ_CP090715:c1221272-1220871 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT231700 NZ_CP126944:1024347-1024613 [Escherichia coli O1:K1:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: B9BI88