Detailed information of TA system TA231689

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1272685..1273384
• Replicon: chromosome
• Accession: NZ_CP090708
• Organism: Burkholderia multivorans strain 2016Y70836300

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: L0Z15_RS21655
• Protein ID: WP_105751843.1
• Coordinates: 1272685..1272981 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9BI88
• Locus tag: L0Z15_RS21660
• Protein ID: WP_006403504.1
• Coordinates: 1272983..1273384 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z15_RS21640 (L0Z15_21640)	1269410..1270951	+	1542	WP_167338149.1	sensor domain-containing diguanylate cyclase	-
L0Z15_RS21645 (L0Z15_21645)	1271158..1271430	+	273	WP_006403506.1	hypothetical protein	-
L0Z15_RS21650 (L0Z15_21650)	1271531..1272565	+	1035	WP_069221065.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
L0Z15_RS21655 (L0Z15_21655)	1272685..1272981	+	297	WP_105751843.1	type II toxin-antitoxin system MqsR family toxin	Toxin
L0Z15_RS21660 (L0Z15_21660)	1272983..1273384	+	402	WP_006403504.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
L0Z15_RS21665 (L0Z15_21665)	1273673..1274233	+	561	WP_105751842.1	GNAT family N-acetyltransferase	-
L0Z15_RS21670 (L0Z15_21670)	1274299..1275240	+	942	WP_035487669.1	ABC transporter substrate-binding protein	-
L0Z15_RS21675 (L0Z15_21675)	1275272..1276333	+	1062	WP_105751841.1	LLM class flavin-dependent oxidoreductase	-
L0Z15_RS21680 (L0Z15_21680)	1276330..1277682	+	1353	WP_006409061.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11128.07 Da
• Isoelectric Point: 9.1122

>T231689 WP_105751843.1 NZ_CP090708:1272685-1272981 [Burkholderia multivorans]
MEKRTAHCKLPRVKALIEAGKVRLTASAVIGARLMGFTEAEAIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T231689 NZ_CP126943:c25199-24912 [Escherichia coli O1:K1:H7]
ATGACTTATACAGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAACAGCAGTTTGC
GAAAAAACTAAAGAAATGCAGCGAAAATCCTCATATTCCTTCCGCAAAACTGCGTGGATTAAAAGACTGCTACAAAATCA
AACTTCGCGCATCGGGGTTTCGTCTGGTCTATCAGGTTATTGATGACATGCTAATTATTGCGGTTGTCGCGGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT231689 WP_006403504.1 NZ_CP090708:1272983-1273384 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT231689 NZ_CP126943:c25447-25196 [Escherichia coli O1:K1:H7]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCGGAACTCTATGAAAGGATGC
TTGATGCGCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Structures

Antitoxin

• AlphaFold DB: B9BI88