Detailed information of TA system TA023167

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 4545231..4545452
• Replicon: chromosome
• Accession: NC_011353
• Organism: Escherichia coli O157:H7 str. EC4115

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: ECH74115_RS33210
• Protein ID: WP_001295224.1
• Coordinates: 4545231..4545338 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4545387..4545452 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECH74115_RS24315	4540484..4541236	-	753	Protein_4498	cellulose biosynthesis protein BcsQ	-
ECH74115_RS24325	4541248..4541436	-	189	WP_001063316.1	YhjR family protein	-
ECH74115_RS24330	4541709..4543280	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
ECH74115_RS24335	4543277..4543468	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
ECH74115_RS24340	4543465..4545144	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
ECH74115_RS33210	4545231..4545338	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4545387..4545452	+	66	NuclAT_16	-	Antitoxin
-	4545387..4545452	+	66	NuclAT_16	-	Antitoxin
-	4545387..4545452	+	66	NuclAT_16	-	Antitoxin
-	4545387..4545452	+	66	NuclAT_16	-	Antitoxin
-	4545387..4545452	+	66	NuclAT_21	-	Antitoxin
-	4545387..4545452	+	66	NuclAT_21	-	Antitoxin
-	4545387..4545452	+	66	NuclAT_21	-	Antitoxin
-	4545387..4545452	+	66	NuclAT_21	-	Antitoxin
ECH74115_RS24355	4545814..4547085	+	1272	WP_001301684.1	amino acid permease	-
ECH74115_RS24360	4547115..4548119	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
ECH74115_RS24365	4548116..4549099	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
ECH74115_RS24370	4549110..4550012	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T23167 WP_001295224.1 NC_011353:c4545338-4545231 [Escherichia coli O157:H7 str. EC4115]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T23167 NC_011353:c4545338-4545231 [Escherichia coli O157:H7 str. EC4115]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT23167 NC_011353:4545387-4545452 [Escherichia coli O157:H7 str. EC4115]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin