Detailed information of TA system TA231660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1679916..1680615
• Replicon: chromosome
• Accession: NZ_CP090698
• Organism: Burkholderia cepacia strain 2017Y70952565VI

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: L0Z01_RS07495
• Protein ID: WP_249481306.1
• Coordinates: 1680319..1680615 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A365QRC5
• Locus tag: L0Z01_RS07490
• Protein ID: WP_059861535.1
• Coordinates: 1679916..1680317 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z01_RS07470 (L0Z01_07470)	1675561..1676913	-	1353	WP_059492206.1	LLM class flavin-dependent oxidoreductase	-
L0Z01_RS07475 (L0Z01_07475)	1676921..1677970	-	1050	WP_021158755.1	LLM class flavin-dependent oxidoreductase	-
L0Z01_RS07480 (L0Z01_07480)	1678034..1678981	-	948	WP_021158756.1	ABC transporter substrate-binding protein	-
L0Z01_RS07485 (L0Z01_07485)	1679038..1679598	-	561	WP_027791642.1	GNAT family N-acetyltransferase	-
L0Z01_RS07490 (L0Z01_07490)	1679916..1680317	-	402	WP_059861535.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
L0Z01_RS07495 (L0Z01_07495)	1680319..1680615	-	297	WP_249481306.1	type II toxin-antitoxin system MqsR family toxin	Toxin
L0Z01_RS07500 (L0Z01_07500)	1680719..1681759	-	1041	WP_027791639.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
L0Z01_RS07505 (L0Z01_07505)	1682002..1682277	-	276	WP_021158762.1	hypothetical protein	-
L0Z01_RS07510 (L0Z01_07510)	1682521..1684071	-	1551	WP_176130484.1	sensor domain-containing diguanylate cyclase	-
L0Z01_RS07515 (L0Z01_07515)	1684070..1684444	+	375	WP_175891902.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11164.96 Da
• Isoelectric Point: 8.0535

>T231660 WP_249481306.1 NZ_CP090698:c1680615-1680319 [Burkholderia cepacia]
MEKRRPHCKLSLVKALVESGQVRLTASAVLGARQLGFTEREALDVVMSLTDLDFHKSMTTYADHTIWQDVYRPLTVRGDV
YLKLTVIDDVLIASFKER

Nucleotide

• Length: 297 bp

>T231660 NZ_CP126940:c4571392-4571219 [Escherichia coli O2:K1:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14572.81 Da
• Isoelectric Point: 8.4869

>AT231660 WP_059861535.1 NZ_CP090698:c1680317-1679916 [Burkholderia cepacia]
MKCPACGAAKLVHDTRDIPYTYKGRSTVVRAITGEFCPACGESVLDLDEATRLGEAISEFNKQVNATIVDPNYIAKVRKK
LRLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Nucleotide

• Length: 402 bp

>AT231660 NZ_CP126940:c4571716-4571420 [Escherichia coli O2:K1:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A365QRC5