Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1228328..1229027 Replicon chromosome
Accession NZ_CP090688
Organism Burkholderia multivorans strain 2017Y71087112III

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag L0Y89_RS05535 Protein ID WP_105836523.1
Coordinates 1228328..1228624 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID -
Locus tag L0Y89_RS05540 Protein ID WP_105836522.1
Coordinates 1228626..1229027 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y89_RS05520 (L0Y89_05520) 1225047..1226591 + 1545 WP_175848070.1 sensor domain-containing diguanylate cyclase -
L0Y89_RS05525 (L0Y89_05525) 1226799..1227071 + 273 WP_105836525.1 hypothetical protein -
L0Y89_RS05530 (L0Y89_05530) 1227174..1228208 + 1035 WP_105836524.1 succinylglutamate desuccinylase/aspartoacylase family protein -
L0Y89_RS05535 (L0Y89_05535) 1228328..1228624 + 297 WP_105836523.1 type II toxin-antitoxin system MqsR family toxin Toxin
L0Y89_RS05540 (L0Y89_05540) 1228626..1229027 + 402 WP_105836522.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
L0Y89_RS05545 (L0Y89_05545) 1229316..1229876 + 561 WP_059786242.1 GNAT family N-acetyltransferase -
L0Y89_RS05550 (L0Y89_05550) 1229942..1230883 + 942 WP_039217954.1 ABC transporter substrate-binding protein -
L0Y89_RS05555 (L0Y89_05555) 1230914..1231975 + 1062 WP_105836521.1 LLM class flavin-dependent oxidoreductase -
L0Y89_RS05560 (L0Y89_05560) 1231972..1233324 + 1353 WP_006413139.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(72-109)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11213.13 Da        Isoelectric Point: 9.1122

>T231631 WP_105836523.1 NZ_CP090688:1228328-1228624 [Burkholderia multivorans]
MEKRTPHCKLPRVKALIEAGKVRLTASAVIGARQMGFTEAETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T231631 NZ_CP126937:2507030-2507308 [Escherichia coli O2:K1:H4]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14419.59 Da        Isoelectric Point: 7.6703

>AT231631 WP_105836522.1 NZ_CP090688:1228626-1229027 [Burkholderia multivorans]
MKCPACGAAALVRDTRDIPYTYKGESTVIPHVTGEFCPACGESVLDVGEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLDEVRAA

Download         Length: 402 bp

>AT231631 NZ_CP126937:2507308-2507592 [Escherichia coli O2:K1:H4]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References