Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1213802..1214501 Replicon chromosome
Accession NZ_CP090681
Organism Burkholderia multivorans strain 2019Y71417852IX

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag L0Z03_RS05475 Protein ID WP_105836523.1
Coordinates 1213802..1214098 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID -
Locus tag L0Z03_RS05480 Protein ID WP_105836522.1
Coordinates 1214100..1214501 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z03_RS05460 (L0Z03_05460) 1210521..1212065 + 1545 WP_175848070.1 sensor domain-containing diguanylate cyclase -
L0Z03_RS05465 (L0Z03_05465) 1212273..1212545 + 273 WP_105836525.1 hypothetical protein -
L0Z03_RS05470 (L0Z03_05470) 1212648..1213682 + 1035 WP_105836524.1 succinylglutamate desuccinylase/aspartoacylase family protein -
L0Z03_RS05475 (L0Z03_05475) 1213802..1214098 + 297 WP_105836523.1 type II toxin-antitoxin system MqsR family toxin Toxin
L0Z03_RS05480 (L0Z03_05480) 1214100..1214501 + 402 WP_105836522.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
L0Z03_RS05485 (L0Z03_05485) 1214790..1215350 + 561 WP_059786242.1 GNAT family N-acetyltransferase -
L0Z03_RS05490 (L0Z03_05490) 1215416..1216357 + 942 WP_039217954.1 ABC transporter substrate-binding protein -
L0Z03_RS05495 (L0Z03_05495) 1216388..1217449 + 1062 WP_105836521.1 LLM class flavin-dependent oxidoreductase -
L0Z03_RS05500 (L0Z03_05500) 1217446..1218798 + 1353 WP_006413139.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(72-109)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11213.13 Da        Isoelectric Point: 9.1122

>T231612 WP_105836523.1 NZ_CP090681:1213802-1214098 [Burkholderia multivorans]
MEKRTPHCKLPRVKALIEAGKVRLTASAVIGARQMGFTEAETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T231612 NZ_CP126934:4094127-4094300 [Escherichia coli O78:H4]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14419.59 Da        Isoelectric Point: 7.6703

>AT231612 WP_105836522.1 NZ_CP090681:1214100-1214501 [Burkholderia multivorans]
MKCPACGAAALVRDTRDIPYTYKGESTVIPHVTGEFCPACGESVLDVGEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLDEVRAA

Download         Length: 402 bp

>AT231612 NZ_CP126934:4093803-4094099 [Escherichia coli O78:H4]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References