Detailed information of TA system TA231603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1311724..1312423
• Replicon: chromosome
• Accession: NZ_CP090678
• Organism: Burkholderia multivorans strain 2019Y71421880II

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: L0Z16_RS05790
• Protein ID: WP_053298526.1
• Coordinates: 1311724..1312020 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9BI88
• Locus tag: L0Z16_RS05795
• Protein ID: WP_006403504.1
• Coordinates: 1312022..1312423 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z16_RS05775 (L0Z16_05775)	1308450..1309991	+	1542	WP_167338149.1	sensor domain-containing diguanylate cyclase	-
L0Z16_RS05780 (L0Z16_05780)	1310197..1310469	+	273	WP_006403506.1	hypothetical protein	-
L0Z16_RS05785 (L0Z16_05785)	1310570..1311604	+	1035	WP_006397017.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
L0Z16_RS05790 (L0Z16_05790)	1311724..1312020	+	297	WP_053298526.1	type II toxin-antitoxin system MqsR family toxin	Toxin
L0Z16_RS05795 (L0Z16_05795)	1312022..1312423	+	402	WP_006403504.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
L0Z16_RS05800 (L0Z16_05800)	1312712..1313272	+	561	WP_069221064.1	GNAT family N-acetyltransferase	-
L0Z16_RS05805 (L0Z16_05805)	1313337..1314278	+	942	WP_059939728.1	ABC transporter substrate-binding protein	-
L0Z16_RS05810 (L0Z16_05810)	1314310..1315371	+	1062	WP_053298524.1	LLM class flavin-dependent oxidoreductase	-
L0Z16_RS05815 (L0Z16_05815)	1315368..1316720	+	1353	WP_006409061.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11173.06 Da
• Isoelectric Point: 9.1122

>T231603 WP_053298526.1 NZ_CP090678:1311724-1312020 [Burkholderia multivorans]
MEKRTAHCKLPRVKALIEAGKVRLTASAVIGARQMGFTEAETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T231603 NZ_CP126934:c2264313-2263915 [Escherichia coli O78:H4]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT231603 WP_006403504.1 NZ_CP090678:1312022-1312423 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT231603 NZ_CP126934:c2264540-2264313 [Escherichia coli O78:H4]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Structures

Antitoxin

• AlphaFold DB: B9BI88