Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4978433..4979114 Replicon chromosome
Accession NZ_CP090649
Organism Pseudomonas aeruginosa strain PA1609

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag L0026_RS23390 Protein ID WP_003111825.1
Coordinates 4978749..4979114 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1C7BMJ2
Locus tag L0026_RS23385 Protein ID WP_003159602.1
Coordinates 4978433..4978756 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0026_RS23345 (L0026_23335) 4973435..4974637 + 1203 WP_052156494.1 DUF3596 domain-containing protein -
L0026_RS23350 4974893..4975315 + 423 WP_071575325.1 type II toxin-antitoxin system MqsR family toxin -
L0026_RS23355 (L0026_23340) 4975312..4975929 + 618 WP_071575326.1 type II toxin-antitoxin system MqsA family antitoxin -
L0026_RS23360 (L0026_23345) 4975926..4976315 + 390 WP_126453026.1 hypothetical protein -
L0026_RS23365 (L0026_23350) 4976643..4976870 + 228 WP_014603215.1 hypothetical protein -
L0026_RS23370 (L0026_23355) 4976885..4977810 - 926 Protein_4639 tyrosine-type recombinase/integrase -
L0026_RS23375 (L0026_23360) 4977810..4978202 - 393 Protein_4640 hypothetical protein -
L0026_RS23380 (L0026_23365) 4978213..4978317 + 105 Protein_4641 IS5/IS1182 family transposase -
L0026_RS23385 (L0026_23370) 4978433..4978756 - 324 WP_003159602.1 XRE family transcriptional regulator Antitoxin
L0026_RS23390 (L0026_23375) 4978749..4979114 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0026_RS23395 (L0026_23380) 4979405..4979579 - 175 Protein_4644 hypothetical protein -
L0026_RS23400 (L0026_23385) 4979786..4980058 + 273 WP_014603216.1 hypothetical protein -
L0026_RS23405 (L0026_23390) 4980088..4980513 - 426 WP_003116492.1 VOC family protein -
L0026_RS23410 (L0026_23395) 4980614..4981498 + 885 WP_016263831.1 LysR substrate-binding domain-containing protein -
L0026_RS23415 (L0026_23400) 4981471..4982424 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
L0026_RS23420 (L0026_23405) 4982645..4983079 + 435 WP_003116494.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T231580 WP_003111825.1 NZ_CP090649:c4979114-4978749 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

>T231580 NZ_CP090649:c4979114-4978749 [Pseudomonas aeruginosa]
GTGGCGTGGGATATCGAGTACACCGACGAGTTCGGTGATTGGTGGGGTTCTCTGTCCGAGGATGAGCAGGAGTCGCTAGC
TGTGACGGTTCGCTTGCTTGAGGAGCGGGGGCCATCCTTGGGGCACCCCCACAGCAGCGGCATCAATGGCTCCCGCCATG
GCCATATGAGAGAGCTACGGACTCAACACGGCGGGCGACCTTTCCGAACGCTTTACGCGTTTGATCCCAGACGCTCCGCG
ATACTGCTGATCGGTGGCGACAAGACTGGCGATGATCGTTGGTACGAATTGAACGTGCCCATTGCCGACCGCCTCTATGA
CGAACACTTGCACCAGCTCCGTGAGGAGGGACTGATCGATGGCTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11882.71 Da        Isoelectric Point: 6.4751

>AT231580 WP_003159602.1 NZ_CP090649:c4978756-4978433 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEGQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT231580 NZ_CP090649:c4978756-4978433 [Pseudomonas aeruginosa]
ATGGCTAAGAAATTCTCCGACCTTCGGGCGCAAATGTCGCCTGAGGGACAGGCCCGCGTCGAGGCCAAGGCCCAGGAACT
GTTGGCTGAAATGCCCCTGAATGAGTTGCGCCAGGCTAGAGGCTTGTCGCAGAAGATGCTGTCTGAAGTGCTGCACGTGC
AGCAGCCGGCAATTGCCAAAATGGAGCGGCGTACGGATATGTACATCTCCACCTTGCGCAGCCACATCGAAGCCATGGGC
GGCCAACTGGAAGTGATTGCACGCTTCCCGGATGGCGCGGTGAAAATCAGCAACTTCGCGGATATCGAAGAGGCGGGCGC
CTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BMJ2

References