Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 140433..141133 Replicon chromosome
Accession NZ_CP090641
Organism Burkholderia contaminans strain LMG 23361

Toxin (Protein)


Gene name mqsR Uniprot ID A0A1E3FT75
Locus tag LXE91_RS18395 Protein ID WP_039357707.1
Coordinates 140433..140729 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A4R4BTY4
Locus tag LXE91_RS18400 Protein ID WP_039357704.1
Coordinates 140732..141133 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE91_RS18380 (LXE91_18305) 136958..138508 + 1551 WP_039357717.1 sensor domain-containing diguanylate cyclase -
LXE91_RS18385 (LXE91_18310) 138750..139034 + 285 WP_039357714.1 hypothetical protein -
LXE91_RS18390 (LXE91_18315) 139286..140329 + 1044 WP_039357711.1 succinylglutamate desuccinylase/aspartoacylase family protein -
LXE91_RS18395 (LXE91_18320) 140433..140729 + 297 WP_039357707.1 type II toxin-antitoxin system MqsR family toxin Toxin
LXE91_RS18400 (LXE91_18325) 140732..141133 + 402 WP_039357704.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
LXE91_RS18405 (LXE91_18330) 141452..142012 + 561 WP_039357701.1 GNAT family N-acetyltransferase -
LXE91_RS18410 (LXE91_18335) 142069..143016 + 948 WP_039357698.1 ABC transporter substrate-binding protein -
LXE91_RS18415 (LXE91_18340) 143069..144118 + 1050 WP_039357696.1 LLM class flavin-dependent oxidoreductase -
LXE91_RS18420 (LXE91_18345) 144126..145478 + 1353 WP_039357693.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(72-109)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11206.04 Da        Isoelectric Point: 8.0535

>T231552 WP_039357707.1 NZ_CP090641:140433-140729 [Burkholderia contaminans]
MEKRTPHCKLPRVKALVETGQVRLTASAVLGARLLGFTEREALDVVLSLTDLDFHKSMTTYADHTIWQDVYRPFTVRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T231552 NZ_CP126928:c2722074-2721972 [Escherichia coli O2:K1:H4]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14649.94 Da        Isoelectric Point: 8.8304

>AT231552 WP_039357704.1 NZ_CP090641:140732-141133 [Burkholderia contaminans]
MKCPACGAARLVRDTRDIPYTYKGRSTVVRDITGDFCPACGESVLDLDEATRLGEAITEFNKQVNATIVDPKYIAKVRKK
LKLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLAEVRAA

Download         Length: 402 bp

>AT231552 NZ_CP126928:2721934-2722202 [Escherichia coli O2:K1:H4]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FT75

Antitoxin

Source ID Structure
AlphaFold DB A0A4R4BTY4

References