Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 741228..742003 Replicon chromosome
Accession NZ_CP090623
Organism Klebsiella pneumoniae isolate KpBO_TO5

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag L0103_RS03695 Protein ID WP_004150910.1
Coordinates 741518..742003 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag L0103_RS03690 Protein ID WP_004150912.1
Coordinates 741228..741521 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0103_RS03670 (L0103_03670) 736436..737038 - 603 WP_002916735.1 short chain dehydrogenase -
L0103_RS03675 (L0103_03675) 737136..738047 + 912 WP_004188550.1 LysR family transcriptional regulator -
L0103_RS03680 (L0103_03680) 738048..739196 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
L0103_RS03685 (L0103_03685) 739207..740583 - 1377 WP_004217775.1 cystathionine beta-synthase -
L0103_RS03690 (L0103_03690) 741228..741521 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
L0103_RS03695 (L0103_03695) 741518..742003 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
L0103_RS03700 (L0103_03700) 742707..743300 + 594 WP_004188553.1 hypothetical protein -
L0103_RS03705 (L0103_03705) 743397..743613 + 217 Protein_729 transposase -
L0103_RS03710 (L0103_03710) 744219..745091 + 873 WP_004188557.1 ParA family protein -
L0103_RS03715 (L0103_03715) 745091..745474 + 384 WP_004150906.1 hypothetical protein -
L0103_RS03720 (L0103_03720) 745467..746834 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 743397..743549 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T231471 WP_004150910.1 NZ_CP090623:741518-742003 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T231471 NZ_CP126539:c2681212-2680685 [Devosia sp. RR2S18]
ATGCCTGAAGGCCCAGCGCCACCGATCATATTGTGGCGGGCCTATGTCCCCCGGTGGTCATATCAACCCTTGTCGGGGGA
GGGGGCTGCTCGGTTCGGCGGCCGATGGAATCCGCTGGGCGTTCCGACCATCTACGCGGCTCGTGAGCTTTCAACGGCCT
GGGCGGAGTACAATCAGGGCTTCGTACAGCATTCAGCTCTGATCGCCCAGTTGCACCTGACTGGCGCATACCTCCCTGAT
TTGACCGTTGCCACAGTCTTGCGACAGTTTGGCTTAGAGGAGAGCATTCATCAGATCGAATGGCGCTCCGATCTCGACAG
CGGCATCGTTCCTGCCACTCACACTGCATATCAAAGACTGGTTGATGCCGGCGCCGATGGCGTCGTCTATCCGTCTTACA
TGTCGCCGGGCGGCACCTGCGTCGCACTTTGGCGTTGGAACCGCCCAGGCCAACCCAGGCTTGAGATCCTTGACCCCGAA
GGCCGGATGCCGAAATCACCGGCGTCCTGGGGGCCTCCCAAAGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT231471 WP_004150912.1 NZ_CP090623:741228-741521 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT231471 NZ_CP126539:c2681576-2681205 [Devosia sp. RR2S18]
ATGCAATCCCAGGGTCTTGAAATTGGTGCCACACGCTTCGGCGATGGTAATTCGCCGTTCCTTTCGGCGCACCGGCTCTC
CGAGCAGCTCGGGCTCCACCAGTCCGAACTCGCGAGGCTAATTGGGATCGCTCGCAATACCCTGGCGGCCAAGTCTGCCA
GTCGGAAGGTCGATGCGGCCCTCAGCCCAATTGTCCGAATTCTGGCCATGGCTGCGGAGATGGCCGGCGATGAAAACCGC
GCGGTGATCTGGTTTAAACATCAGCCCATCCCGGGATGGGCTGGCAAGACCGCCTATGATCTCGTTGGAGAGGGGAAGAG
CGATCGCGTTCTGGCCTATCTCGAGGCTGTTCGTTCGGGCGTTTATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References