Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 14310..14953 Replicon plasmid pKP19-3138-5
Accession NZ_CP090621
Organism Klebsiella pneumoniae strain KP19-3138

Toxin (Protein)


Gene name vagD Uniprot ID Q84A06
Locus tag LXT11_RS02360 Protein ID WP_000754566.1
Coordinates 14310..14726 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag LXT11_RS02365 Protein ID WP_001261276.1
Coordinates 14723..14953 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXT11_RS02345 (LXT11_02345) 9436..10272 + 837 WP_047671991.1 S-formylglutathione hydrolase -
LXT11_RS02350 (LXT11_02350) 10300..10935 - 636 WP_000470623.1 recombinase family protein -
LXT11_RS02355 (LXT11_02355) 11103..14090 + 2988 WP_000124025.1 Tn3 family transposase -
LXT11_RS02360 (LXT11_02360) 14310..14726 - 417 WP_000754566.1 type II toxin-antitoxin system VapC family toxin Toxin
LXT11_RS02365 (LXT11_02365) 14723..14953 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LXT11_RS02370 (LXT11_02370) 15527..15877 + 351 WP_000493378.1 hypothetical protein -
LXT11_RS02375 (LXT11_02375) 15928..16671 + 744 WP_000129823.1 hypothetical protein -
LXT11_RS02380 (LXT11_02380) 16668..17444 + 777 WP_000015958.1 site-specific integrase -
LXT11_RS02385 (LXT11_02385) 17502..17759 - 258 WP_000764642.1 hypothetical protein -
LXT11_RS02390 (LXT11_02390) 17888..17992 - 105 WP_032409716.1 hypothetical protein -
LXT11_RS02395 (LXT11_02395) 18522..19388 + 867 WP_004118283.1 replication initiation protein -
LXT11_RS02400 (LXT11_02400) 19565..19834 - 270 WP_000339857.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid mph(A) / aph(3')-Ia / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / sul1 / qnrB4 / blaDHA-1 - 1..65184 65184


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15006.52 Da        Isoelectric Point: 9.2957

>T231452 WP_000754566.1 NZ_CP090621:c14726-14310 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK

Download         Length: 417 bp

>T231452 NZ_CP126536:c77861-77520 [Citrobacter freundii]
ATGAAACCTCAACCTGCAACAACTTCGCGGGCGGCTGAGCTATATCTGTCGCCAGTGGCGGTGTGGCAAATGCTACTGAC
ACGCCTGCTGGAGCAGCACTATGGCCTGACACTGAACGACACGCCATTTAGTGATGAAACCGTTATTCAGGAACACATTG
ATGCCGGGATCATGCTGGCCGATGCTGTGAATTTTCTGGTGGAGAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCGCCTTATCTTCGGGCTGTAGATATTTTACGGGCAAGACAGGCAACTGGCCTGTTGCGACAAAG
CCGTAACAACGCAGTACGGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT231452 WP_001261276.1 NZ_CP090621:c14953-14723 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT231452 NZ_CP126536:c78202-77882 [Citrobacter freundii]
ATGAGAAGTAACATCACATGGGGCCTGCAGCGGGATATCACGCCGTGCATGGGAGCACGTCTGGTGCAGGAGGGTAACCG
GCTGCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGACGAATGTCTTAAGCTGGATGTGGTATTTC
CACATTTTATCAGCCGGATCGAGTCTATGCTGACCACTGGTGAATTGAATCCCCGTCATGCCCACTGCATCACCATTTAC
CACAACGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGCCTACGTATATGTAGTCGTCTATTCCACTCAACGCTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A387K1G3

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References