Detailed information of TA system TA231450

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 94075..94328
• Replicon: plasmid pKP19-3138-4
• Accession: NZ_CP090620
• Organism: Klebsiella pneumoniae strain KP19-3138

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: G9G1E3
• Locus tag: LXT11_RS02275
• Protein ID: WP_001312851.1
• Coordinates: 94179..94328 (+)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	94075..94134 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXT11_RS02250 (90802)	90802..91548	+	747	WP_000205770.1	conjugal transfer pilus acetylase TraX	-
LXT11_RS02255 (91603)	91603..92163	+	561	WP_000139328.1	fertility inhibition protein FinO	-
LXT11_RS02260 (92295)	92295..92495	+	201	WP_015059022.1	hypothetical protein	-
LXT11_RS02265 (92881)	92881..93480	+	600	WP_032083981.1	PIN domain-containing protein	-
LXT11_RS02270 (93542)	93542..93874	+	333	WP_152916585.1	hypothetical protein	-
- (94075)	94075..94134	-	60	NuclAT_1	-	Antitoxin
- (94075)	94075..94134	-	60	NuclAT_1	-	Antitoxin
- (94075)	94075..94134	-	60	NuclAT_1	-	Antitoxin
- (94075)	94075..94134	-	60	NuclAT_1	-	Antitoxin
LXT11_RS02275 (94179)	94179..94328	+	150	WP_001312851.1	Hok/Gef family protein	Toxin
LXT11_RS02280 (94612)	94612..94860	+	249	WP_000083837.1	replication regulatory protein RepA	-
LXT11_RS02285 (94975)	94975..95159	+	185	Protein_117	protein CopA/IncA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	dfrA14 / rmtB / floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / fosA3 / blaTEM-1B / blaCTX-M-55	-	1..95171	95171

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5542.67 Da
• Isoelectric Point: 8.7678

>T231450 WP_001312851.1 NZ_CP090620:94179-94328 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 150 bp

>T231450 NZ_CP126534:c3208792-3208442 [Bacillus inaquosorum]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT231450 NZ_CP090620:c94134-94075 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A829C8K5

Antitoxin