Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 54597..54866 Replicon plasmid pKP19-3138-4
Accession NZ_CP090620
Organism Klebsiella pneumoniae strain KP19-3138

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag LXT11_RS02045 Protein ID WP_001372321.1
Coordinates 54741..54866 (+) Length 42 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 54597..54662 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXT11_RS02015 50307..50834 + 528 WP_000290834.1 single-stranded DNA-binding protein -
LXT11_RS02020 50892..51125 + 234 WP_000006003.1 DUF905 family protein -
LXT11_RS02025 51186..53209 + 2024 Protein_65 ParB/RepB/Spo0J family partition protein -
LXT11_RS02030 53278..53712 + 435 WP_000845953.1 conjugation system SOS inhibitor PsiB -
LXT11_RS02035 53709..54428 + 720 WP_001276217.1 plasmid SOS inhibition protein A -
- 54440..54664 + 225 NuclAT_0 - -
- 54440..54664 + 225 NuclAT_0 - -
- 54440..54664 + 225 NuclAT_0 - -
- 54440..54664 + 225 NuclAT_0 - -
- 54597..54662 - 66 - - Antitoxin
LXT11_RS02040 54650..54799 + 150 Protein_68 plasmid maintenance protein Mok -
LXT11_RS02045 54741..54866 + 126 WP_001372321.1 type I toxin-antitoxin system Hok family toxin Toxin
LXT11_RS02050 55185..55481 - 297 Protein_70 hypothetical protein -
LXT11_RS02055 55781..56077 + 297 WP_001272251.1 hypothetical protein -
LXT11_RS02060 56188..57009 + 822 WP_001234445.1 DUF932 domain-containing protein -
LXT11_RS02065 57306..57953 - 648 WP_015059008.1 transglycosylase SLT domain-containing protein -
LXT11_RS02070 58230..58613 + 384 WP_000124981.1 conjugal transfer relaxosome DNA-binding protein TraM -
LXT11_RS02075 58804..59490 + 687 WP_015059009.1 PAS domain-containing protein -
LXT11_RS02080 59584..59811 + 228 WP_001254386.1 conjugal transfer relaxosome protein TraY -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA14 / rmtB / floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / fosA3 / blaTEM-1B / blaCTX-M-55 - 1..95171 95171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-37)


Sequences


Toxin        


Download         Length: 42 a.a.        Molecular weight: 4780.69 Da        Isoelectric Point: 8.5110

>T231447 WP_001372321.1 NZ_CP090620:54741-54866 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 126 bp

>T231447 NZ_CP126530:526742-527092 [Bacillus halotolerans]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAGATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 66 bp

>AT231447 NZ_CP090620:c54662-54597 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References