Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 54597..54866 | Replicon | plasmid pKP19-3138-4 |
Accession | NZ_CP090620 | ||
Organism | Klebsiella pneumoniae strain KP19-3138 |
Toxin (Protein)
Gene name | hok | Uniprot ID | - |
Locus tag | LXT11_RS02045 | Protein ID | WP_001372321.1 |
Coordinates | 54741..54866 (+) | Length | 42 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 54597..54662 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LXT11_RS02015 | 50307..50834 | + | 528 | WP_000290834.1 | single-stranded DNA-binding protein | - |
LXT11_RS02020 | 50892..51125 | + | 234 | WP_000006003.1 | DUF905 family protein | - |
LXT11_RS02025 | 51186..53209 | + | 2024 | Protein_65 | ParB/RepB/Spo0J family partition protein | - |
LXT11_RS02030 | 53278..53712 | + | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
LXT11_RS02035 | 53709..54428 | + | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
- | 54440..54664 | + | 225 | NuclAT_0 | - | - |
- | 54440..54664 | + | 225 | NuclAT_0 | - | - |
- | 54440..54664 | + | 225 | NuclAT_0 | - | - |
- | 54440..54664 | + | 225 | NuclAT_0 | - | - |
- | 54597..54662 | - | 66 | - | - | Antitoxin |
LXT11_RS02040 | 54650..54799 | + | 150 | Protein_68 | plasmid maintenance protein Mok | - |
LXT11_RS02045 | 54741..54866 | + | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
LXT11_RS02050 | 55185..55481 | - | 297 | Protein_70 | hypothetical protein | - |
LXT11_RS02055 | 55781..56077 | + | 297 | WP_001272251.1 | hypothetical protein | - |
LXT11_RS02060 | 56188..57009 | + | 822 | WP_001234445.1 | DUF932 domain-containing protein | - |
LXT11_RS02065 | 57306..57953 | - | 648 | WP_015059008.1 | transglycosylase SLT domain-containing protein | - |
LXT11_RS02070 | 58230..58613 | + | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
LXT11_RS02075 | 58804..59490 | + | 687 | WP_015059009.1 | PAS domain-containing protein | - |
LXT11_RS02080 | 59584..59811 | + | 228 | WP_001254386.1 | conjugal transfer relaxosome protein TraY | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | dfrA14 / rmtB / floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / fosA3 / blaTEM-1B / blaCTX-M-55 | - | 1..95171 | 95171 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T231447 WP_001372321.1 NZ_CP090620:54741-54866 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T231447 NZ_CP126530:526742-527092 [Bacillus halotolerans]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAGATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAGATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 66 bp
>AT231447 NZ_CP090620:c54662-54597 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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