Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 26733..27159 | Replicon | plasmid pDCE7-2 |
| Accession | NZ_CP090613 | ||
| Organism | Escherichia coli isolate DCE7 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | LZG50_RS24150 | Protein ID | WP_001372321.1 |
| Coordinates | 26733..26858 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 26935..27159 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZG50_RS24110 (21751) | 21751..21978 | - | 228 | WP_000089263.1 | conjugal transfer relaxosome protein TraY | - |
| LZG50_RS24115 (22115) | 22115..22786 | - | 672 | WP_000283561.1 | conjugal transfer transcriptional regulator TraJ | - |
| LZG50_RS24120 (22980) | 22980..23363 | - | 384 | WP_001354030.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| LZG50_RS24125 (23686) | 23686..24288 | + | 603 | WP_000243709.1 | transglycosylase SLT domain-containing protein | - |
| LZG50_RS24130 (24585) | 24585..25406 | - | 822 | WP_001234469.1 | DUF932 domain-containing protein | - |
| LZG50_RS24135 (25527) | 25527..25814 | - | 288 | WP_000107537.1 | hypothetical protein | - |
| LZG50_RS24140 (26112) | 26112..26285 | + | 174 | Protein_40 | hypothetical protein | - |
| LZG50_RS24145 (26283) | 26283..26513 | - | 231 | WP_071587244.1 | hypothetical protein | - |
| LZG50_RS24150 (26733) | 26733..26858 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| LZG50_RS24155 (26800) | 26800..26949 | - | 150 | Protein_43 | plasmid maintenance protein Mok | - |
| - (26935) | 26935..27159 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (26935) | 26935..27159 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (26935) | 26935..27159 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (26935) | 26935..27159 | - | 225 | NuclAT_0 | - | Antitoxin |
| LZG50_RS24160 (26971) | 26971..27159 | + | 189 | WP_123002541.1 | protein sok | - |
| LZG50_RS24165 (27104) | 27104..27890 | - | 787 | Protein_45 | plasmid SOS inhibition protein A | - |
| LZG50_RS24170 (27887) | 27887..28321 | - | 435 | WP_000845922.1 | conjugation system SOS inhibitor PsiB | - |
| LZG50_RS24175 (28376) | 28376..30334 | - | 1959 | WP_234732947.1 | ParB/RepB/Spo0J family partition protein | - |
| LZG50_RS24180 (30393) | 30393..30626 | - | 234 | WP_000006004.1 | DUF905 domain-containing protein | - |
| LZG50_RS24185 (30682) | 30682..31209 | - | 528 | WP_000290793.1 | single-stranded DNA-binding protein | - |
| LZG50_RS24190 (31679) | 31679..31939 | - | 261 | WP_071600428.1 | hypothetical protein | - |
| LZG50_RS24195 (31849) | 31849..32091 | - | 243 | WP_001299722.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T231437 WP_001372321.1 NZ_CP090613:c26858-26733 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T231437 NZ_CP126496:c2109639-2108893 [Bacillus paralicheniformis]
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTCATTGTTTTGGCGCTGGCTCTGTATGTAGCTGCCGTGTGGCGTTTTGA
AAAAAAGCTCACCGAAAAAACGGTCGCGATCCGAAAAACGTGGTACCTGCTTTATGTTATCGGCGCCGTGATTTATTGGA
CGCACGATCCGCAGTCGATTTTCACAAACCCGCTTCATTACTTGATCGTTGCCGTTTTTTTCACGCTGACAGACGCTTTT
ATTTTCTTAAACGCCTACTTTAAAAAGCTCGGCAGCTCCGAACTCGCGACAGACACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACATATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAACGAACCGATCCACATCTATTATG
GAAATATAGAAGCGTATGCAGAAGGGATCGAAAAGCTCATCAAACGGTTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAGGATCATTTGCTTGAGCATATGGAAAACCGGTTCGATGTTCAAGAAAAGCTTGA
GCGCAAAGACGTTTATTATGAAGAAAACGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGACTACCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGAAGGTGACGACTGA
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTCATTGTTTTGGCGCTGGCTCTGTATGTAGCTGCCGTGTGGCGTTTTGA
AAAAAAGCTCACCGAAAAAACGGTCGCGATCCGAAAAACGTGGTACCTGCTTTATGTTATCGGCGCCGTGATTTATTGGA
CGCACGATCCGCAGTCGATTTTCACAAACCCGCTTCATTACTTGATCGTTGCCGTTTTTTTCACGCTGACAGACGCTTTT
ATTTTCTTAAACGCCTACTTTAAAAAGCTCGGCAGCTCCGAACTCGCGACAGACACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACATATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAACGAACCGATCCACATCTATTATG
GAAATATAGAAGCGTATGCAGAAGGGATCGAAAAGCTCATCAAACGGTTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAGGATCATTTGCTTGAGCATATGGAAAACCGGTTCGATGTTCAAGAAAAGCTTGA
GCGCAAAGACGTTTATTATGAAGAAAACGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGACTACCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGAAGGTGACGACTGA
Antitoxin
Download Length: 225 bp
>AT231437 NZ_CP090613:c27159-26935 [Escherichia coli]
TCACACGGATTGCCCGTGAACTGGCTGAACGACCAGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTGCCCGTGAACTGGCTGAACGACCAGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
