231418

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1845928..1846430 Replicon chromosome
Accession NZ_CP090611
Organism Escherichia coli isolate DCE7

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag LZG50_RS08845 Protein ID WP_000767829.1
Coordinates 1846176..1846430 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag LZG50_RS08840 Protein ID WP_001259255.1
Coordinates 1845928..1846179 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG50_RS08815 (1841107) 1841107..1842174 - 1068 WP_001563571.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
LZG50_RS08820 (1842174) 1842174..1843244 - 1071 WP_000108943.1 histidinol-phosphate transaminase -
LZG50_RS08825 (1843241) 1843241..1844545 - 1305 WP_001563570.1 histidinol dehydrogenase -
LZG50_RS08830 (1844551) 1844551..1845450 - 900 WP_000131774.1 ATP phosphoribosyltransferase -
LZG50_RS08835 (1845596) 1845596..1845646 - 51 WP_001364200.1 his operon leader peptide -
LZG50_RS08840 (1845928) 1845928..1846179 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LZG50_RS08845 (1846176) 1846176..1846430 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
LZG50_RS08850 (1846513) 1846513..1847337 + 825 WP_000754737.1 SDR family oxidoreductase -
LZG50_RS08855 (1847383) 1847383..1848312 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
LZG50_RS08860 (1848527) 1848527..1848589 + 63 WP_010723108.1 membrane protein YoeI -
LZG50_RS08865 (1848579) 1848579..1849937 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T231418 WP_000767829.1 NZ_CP090611:1846176-1846430 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T231418 NZ_CP126348:2603890-2603997 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT231418 WP_001259255.1 NZ_CP090611:1845928-1846179 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT231418 NZ_CP126348:c2603837-2603776 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References