231412

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 213623..214941 Replicon chromosome
Accession NZ_CP090611
Organism Escherichia coli isolate DCE7

Toxin (Protein)


Gene name HipT Uniprot ID B7UL96
Locus tag LZG50_RS01070 Protein ID WP_001262465.1
Coordinates 213934..214941 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID B7UL97
Locus tag LZG50_RS01065 Protein ID WP_001346664.1
Coordinates 213623..213934 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG50_RS01040 (209155) 209155..210174 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
LZG50_RS01045 (210184) 210184..211086 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
LZG50_RS01050 (211097) 211097..212080 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
LZG50_RS01055 (212077) 212077..213090 + 1014 WP_000103582.1 dipeptide ABC transporter ATP-binding subunit DppF -
LZG50_RS01060 (213315) 213315..213638 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
LZG50_RS01065 (213623) 213623..213934 + 312 WP_001346664.1 HipA N-terminal domain-containing protein Antitoxin
LZG50_RS01070 (213934) 213934..214941 + 1008 WP_001262465.1 HipA domain-containing protein Toxin
LZG50_RS01075 (214958) 214958..216229 - 1272 WP_001339917.1 aromatic amino acid transport family protein -
- (216591) 216591..216656 - 66 NuclAT_19 - -
- (216591) 216591..216656 - 66 NuclAT_19 - -
- (216591) 216591..216656 - 66 NuclAT_19 - -
- (216591) 216591..216656 - 66 NuclAT_19 - -
- (216591) 216591..216656 - 66 NuclAT_25 - -
- (216591) 216591..216656 - 66 NuclAT_25 - -
- (216591) 216591..216656 - 66 NuclAT_25 - -
- (216591) 216591..216656 - 66 NuclAT_25 - -
LZG50_RS01080 (216705) 216705..216812 + 108 WP_000170747.1 type I toxin-antitoxin system toxin Ldr family protein -
- (217074) 217074..217139 - 66 NuclAT_18 - -
- (217074) 217074..217139 - 66 NuclAT_18 - -
- (217074) 217074..217139 - 66 NuclAT_18 - -
- (217074) 217074..217139 - 66 NuclAT_18 - -
- (217074) 217074..217139 - 66 NuclAT_24 - -
- (217074) 217074..217139 - 66 NuclAT_24 - -
- (217074) 217074..217139 - 66 NuclAT_24 - -
- (217074) 217074..217139 - 66 NuclAT_24 - -
LZG50_RS01085 (217188) 217188..217295 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
LZG50_RS01090 (217381) 217381..219060 - 1680 WP_000191555.1 cellulose biosynthesis protein BcsG -
LZG50_RS01095 (219057) 219057..219248 - 192 WP_000988310.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-99)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38329.55 Da        Isoelectric Point: 5.4135

>T231412 WP_001262465.1 NZ_CP090611:213934-214941 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLNPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQITD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFYSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

>T231412 NZ_CP126348:1320550-1320948 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11831.41 Da        Isoelectric Point: 6.3215

>AT231412 WP_001346664.1 NZ_CP090611:213623-213934 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAHDYHGPAISISLPVAQRQFPSETLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp

>AT231412 NZ_CP126348:1320323-1320550 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AB4
PDB 7AB5
PDB 7AB3

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5V9L6

References