Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1799441..1800098 Replicon chromosome
Accession NZ_CP090609
Organism Burkholderia cepacia strain CMCC(B)23005

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LZ568_RS26075 Protein ID WP_059696229.1
Coordinates 1799766..1800098 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LZ568_RS26070 Protein ID WP_059696189.1
Coordinates 1799441..1799773 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ568_RS26055 (LZ568_26055) 1796920..1797309 + 390 WP_027790003.1 fucose-binding lectin II -
LZ568_RS26060 (LZ568_26060) 1797434..1798255 + 822 WP_059696184.1 fucose-binding lectin II -
LZ568_RS26065 (LZ568_26065) 1798409..1799254 + 846 WP_059696186.1 AraC family transcriptional regulator -
LZ568_RS26070 (LZ568_26070) 1799441..1799773 - 333 WP_059696189.1 helix-turn-helix transcriptional regulator Antitoxin
LZ568_RS26075 (LZ568_26075) 1799766..1800098 - 333 WP_059696229.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ568_RS26080 (LZ568_26080) 1800388..1801752 - 1365 WP_059696191.1 M23 family metallopeptidase -
LZ568_RS26085 (LZ568_26085) 1802093..1802962 + 870 WP_059696193.1 mechanosensitive ion channel family protein -
LZ568_RS26090 (LZ568_26090) 1803043..1804185 - 1143 WP_059696195.1 branched-chain amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1799441..1815673 16232


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-105)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12905.09 Da        Isoelectric Point: 9.8813

>T231407 WP_059696229.1 NZ_CP090609:c1800098-1799766 [Burkholderia cepacia]
MKKWTILYYDERVKRDVFALPKGILAGYLLLIEAMEEHGADLRMPYSRAMGEGLFELRPRGREGIGRVFYCIRVGYELVV
LHSFVKKTQETPNDELQIARRRMKEVRNNG

Download         Length: 333 bp

>T231407 NZ_CP126348:290864-291391 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12015.57 Da        Isoelectric Point: 8.0521

>AT231407 WP_059696189.1 NZ_CP090609:c1799773-1799441 [Burkholderia cepacia]
MAKARPTHTSEERYAPVRHTAEDTARLLTDPAIKAEYDALEEEFTALRALLDARKDAGLTQAQIAERMGTTTSAVSRLEA
SFSSEKHSPSFATLRKYAAACGKKLVISFA

Download         Length: 333 bp

>AT231407 NZ_CP126348:290591-290857 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References