Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 25959..26631 Replicon chromosome
Accession NZ_CP090595
Organism Pectobacterium aroidearum strain QJ011

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L0Y21_RS00115 Protein ID WP_180779426.1
Coordinates 26245..26631 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L0Y21_RS00110 Protein ID WP_180779427.1
Coordinates 25959..26258 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y21_RS00090 (L0Y21_00090) 21194..22201 + 1008 WP_256599202.1 nucleoside hydrolase -
L0Y21_RS00095 (L0Y21_00095) 22201..23178 + 978 WP_012772765.1 ABC transporter permease -
L0Y21_RS00100 (L0Y21_00100) 23175..24083 + 909 WP_012772766.1 ABC transporter permease -
L0Y21_RS00105 (L0Y21_00105) 24123..25922 + 1800 WP_205947324.1 ABC transporter ATP-binding protein -
L0Y21_RS00110 (L0Y21_00110) 25959..26258 - 300 WP_180779427.1 XRE family transcriptional regulator Antitoxin
L0Y21_RS00115 (L0Y21_00115) 26245..26631 - 387 WP_180779426.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y21_RS00120 (L0Y21_00120) 26847..27344 + 498 WP_225181733.1 GNAT family N-acetyltransferase -
L0Y21_RS00125 (L0Y21_00125) 27543..27800 - 258 WP_012772768.1 DUF1471 domain-containing protein -
L0Y21_RS00130 (L0Y21_00130) 27973..28773 - 801 WP_194431341.1 aliphatic sulfonates ABC transporter ATP-binding protein -
L0Y21_RS00135 (L0Y21_00135) 28770..29564 - 795 WP_180779424.1 aliphatic sulfonate ABC transporter permease SsuC -
L0Y21_RS00140 (L0Y21_00140) 29575..30717 - 1143 WP_180779423.1 FMNH2-dependent alkanesulfonate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14834.84 Da        Isoelectric Point: 4.7331

>T231366 WP_180779426.1 NZ_CP090595:c26631-26245 [Pectobacterium aroidearum]
MEVYRLAWEIVTRALFDTWFDEQTETVQEEVLAHLGILEEDGPQLGRPQVDQIKGSQYKNMKELRVQVGGHPFRTFFAFD
RTRKAIVLCAGDKKGENEKLFYERMIKIADAEFTSHLISPEVKEDGDI

Download         Length: 387 bp

>T231366 NZ_CP126343:875862-876269 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11082.10 Da        Isoelectric Point: 10.6442

>AT231366 WP_180779427.1 NZ_CP090595:c26258-25959 [Pectobacterium aroidearum]
MATFKEMMAKRSPESRARIEARTAEIRQEITLAKLREELNMSQTQLALALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPDGKRIALTL

Download         Length: 300 bp

>AT231366 NZ_CP126343:875615-875881 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References