Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 29235..29907 Replicon chromosome
Accession NZ_CP090594
Organism Pectobacterium aroidearum strain QJ034

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L0Y22_RS00135 Protein ID WP_180779426.1
Coordinates 29521..29907 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L0Y22_RS00130 Protein ID WP_180779427.1
Coordinates 29235..29534 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y22_RS00110 (L0Y22_00110) 24470..25477 + 1008 WP_256542658.1 nucleoside hydrolase -
L0Y22_RS00115 (L0Y22_00115) 25477..26454 + 978 WP_012772765.1 ABC transporter permease -
L0Y22_RS00120 (L0Y22_00120) 26451..27359 + 909 WP_012772766.1 ABC transporter permease -
L0Y22_RS00125 (L0Y22_00125) 27399..29198 + 1800 WP_256542659.1 ABC transporter ATP-binding protein -
L0Y22_RS00130 (L0Y22_00130) 29235..29534 - 300 WP_180779427.1 XRE family transcriptional regulator Antitoxin
L0Y22_RS00135 (L0Y22_00135) 29521..29907 - 387 WP_180779426.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y22_RS00140 (L0Y22_00140) 30123..30620 + 498 WP_182100740.1 GNAT family N-acetyltransferase -
L0Y22_RS00145 (L0Y22_00145) 30820..31077 - 258 WP_012772768.1 DUF1471 domain-containing protein -
L0Y22_RS00150 (L0Y22_00150) 31250..32050 - 801 WP_181845728.1 aliphatic sulfonates ABC transporter ATP-binding protein -
L0Y22_RS00155 (L0Y22_00155) 32047..32841 - 795 WP_180779424.1 aliphatic sulfonate ABC transporter permease SsuC -
L0Y22_RS00160 (L0Y22_00160) 32852..33994 - 1143 WP_180779423.1 FMNH2-dependent alkanesulfonate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14834.84 Da        Isoelectric Point: 4.7331

>T231353 WP_180779426.1 NZ_CP090594:c29907-29521 [Pectobacterium aroidearum]
MEVYRLAWEIVTRALFDTWFDEQTETVQEEVLAHLGILEEDGPQLGRPQVDQIKGSQYKNMKELRVQVGGHPFRTFFAFD
RTRKAIVLCAGDKKGENEKLFYERMIKIADAEFTSHLISPEVKEDGDI

Download         Length: 387 bp

>T231353 NZ_CP126341:633859-634143 [Enterobacter cloacae]
ATGACTTATGAACTGGAATTTGACCCGAGGGCGTTAAAAGAGTGGAGCAAGCTGGGGGAGACTGTAAAAAAGCAGTTCAG
GAAGAAACTTGCCGGGGTGTTGGTAAACCCCCGGATCGAATCGGCCCGTCTGCATAATCTGCCTGATTGCTACAAAATAA
AACTCAGATCCCAGGGTTACCGTTTGGTCTATCAGGTTCAGGACAACGTGGTAACGGTAGTTGTCATCGCTATTGGGAAA
AGAGAGAAATTAACCGTGTATCACGATGCTAACAAACGGCTATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11082.10 Da        Isoelectric Point: 10.6442

>AT231353 WP_180779427.1 NZ_CP090594:c29534-29235 [Pectobacterium aroidearum]
MATFKEMMAKRSPESRARIEARTAEIRQEITLAKLREELNMSQTQLALALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPDGKRIALTL

Download         Length: 300 bp

>AT231353 NZ_CP126341:633627-633869 [Enterobacter cloacae]
ATGGCTACGCTTAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATCACCCC
AACAGAAGCCGTGCGACTCCTGTTTCAGTATGTCGCCGAGACGGGACGCATGCCGGTGAAAACGGTCACGATTAGCGACA
GCGAAGATGCGCTGATACAGACAGTCCGGGAGCGACTGGCTAATCCGCAAAAGGGAATTAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References