Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4297918..4298420 Replicon chromosome
Accession NZ_CP090593
Organism Pectobacterium aroidearum strain QJ036

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7W2E5L4
Locus tag L0Y29_RS19215 Protein ID WP_039282578.1
Coordinates 4298166..4298420 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W2E625
Locus tag L0Y29_RS19210 Protein ID WP_039324900.1
Coordinates 4297918..4298169 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y29_RS19195 (L0Y29_19170) 4294318..4295277 + 960 WP_012773138.1 ABC transporter permease -
L0Y29_RS19200 (L0Y29_19175) 4295270..4296136 + 867 WP_181829899.1 ABC transporter permease -
L0Y29_RS19205 (L0Y29_19180) 4296133..4297842 + 1710 WP_256542474.1 ABC transporter ATP-binding protein -
L0Y29_RS19210 (L0Y29_19185) 4297918..4298169 + 252 WP_039324900.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
L0Y29_RS19215 (L0Y29_19190) 4298166..4298420 + 255 WP_039282578.1 Txe/YoeB family addiction module toxin Toxin
L0Y29_RS19220 (L0Y29_19195) 4298480..4299334 - 855 WP_256542475.1 helix-turn-helix domain-containing protein -
L0Y29_RS19225 (L0Y29_19200) 4299359..4300198 - 840 WP_194431515.1 HTH-type transcriptional activator RhaS -
L0Y29_RS19230 (L0Y29_19205) 4300534..4302024 + 1491 WP_256542476.1 rhamnulokinase -
L0Y29_RS19235 (L0Y29_19210) 4302021..4303283 + 1263 WP_181845053.1 L-rhamnose isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10229.79 Da        Isoelectric Point: 8.0353

>T231350 WP_039282578.1 NZ_CP090593:4298166-4298420 [Pectobacterium aroidearum]
VKLIWSEEAWEDYLYWQDIDKRMVKKINELIKETRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITDDAMMIAAC
RYHY

Download         Length: 255 bp

>T231350 NZ_CP126341:59876-60274 [Enterobacter cloacae]
ATGCTGCATATGTTGGATACAAACATAGTAAGCCACCTCGTCAGGCAACATCCCGGGGTGATAAAGCACTATTCTCGCAC
CCCAATAGAAAAAATGTGTATTTCAAGCGTGACGGAGGCTGAACTGCTTTATGGAATAGCCAAAAAGCAAAGTGACAGAT
TACAAAAAACAATACTTGAGTTCCTTAAAACCATCACTATTTGCGACTGGGACAGTGAAGCCGCAGCAACGTACGGTGAA
CTCCGCGCAGAAATGGAGAAGAGAGGGAGAGTGATGGGCGATCTCGATCAACTGATCGCTGCGCATGCTCTTAGTCGGGG
TACAACAATAGTGACCAACGATCATGCATTCAGAATGGTGCAGGCGCTTGCCGTTGAGGACTGGACAACAGCGTCGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9367.64 Da        Isoelectric Point: 4.6119

>AT231350 WP_039324900.1 NZ_CP090593:4297918-4298169 [Pectobacterium aroidearum]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNSIESLKAGNGEERD
IIE

Download         Length: 252 bp

>AT231350 NZ_CP126341:59612-59872 [Enterobacter cloacae]
ATGAAACGTACAGCAAAACTCTTCAAAAAGGGGCGACGTCAGGCAGTGATGTTGCCTGCTGACTTCATGTTTGATACGGA
GAGTGTTTACATCCGACGAGATGAGGAAGGGAACGTCATCTTGACTGCGAGATCGGAAAAGGAGCGTCACAGAGATAATT
TTTTACGTTTACTGAAGCAGACTGATGTTCCTGATTCTTTCCTGAGCAAAGAGGAACGCAATCAGAGCTATACAACAAGA
GATCCATTTGAAGGGTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2E5L4

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E625

References