Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4451740..4452242 Replicon chromosome
Accession NZ_CP090588
Organism Pectobacterium aroidearum strain AK042

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7W2E5L4
Locus tag L0Y25_RS20155 Protein ID WP_039282578.1
Coordinates 4451988..4452242 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W2E625
Locus tag L0Y25_RS20150 Protein ID WP_039324900.1
Coordinates 4451740..4451991 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y25_RS20135 (L0Y25_20110) 4448140..4449099 + 960 WP_256553901.1 ABC transporter permease -
L0Y25_RS20140 (L0Y25_20115) 4449092..4449958 + 867 WP_010285293.1 ABC transporter permease -
L0Y25_RS20145 (L0Y25_20120) 4449955..4451664 + 1710 WP_256553902.1 ABC transporter ATP-binding protein -
L0Y25_RS20150 (L0Y25_20125) 4451740..4451991 + 252 WP_039324900.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
L0Y25_RS20155 (L0Y25_20130) 4451988..4452242 + 255 WP_039282578.1 Txe/YoeB family addiction module toxin Toxin
L0Y25_RS20160 (L0Y25_20135) 4452281..4453135 - 855 WP_256553903.1 helix-turn-helix domain-containing protein -
L0Y25_RS20165 (L0Y25_20140) 4453160..4453999 - 840 WP_180778897.1 HTH-type transcriptional activator RhaS -
L0Y25_RS20170 (L0Y25_20145) 4454335..4455825 + 1491 WP_256553904.1 rhamnulokinase -
L0Y25_RS20175 (L0Y25_20150) 4455822..4457084 + 1263 WP_181845053.1 L-rhamnose isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10229.79 Da        Isoelectric Point: 8.0353

>T231287 WP_039282578.1 NZ_CP090588:4451988-4452242 [Pectobacterium aroidearum]
VKLIWSEEAWEDYLYWQDIDKRMVKKINELIKETRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITDDAMMIAAC
RYHY

Download         Length: 255 bp

>T231287 NZ_CP126323:3569490-3569618 [Salmonella enterica subsp. enterica]
GTGAAGATTTCGGACGGGTGTATTGTGCTAATGGCGGACGGTAACGAGGTGCAGGAGCTGCGCGAACAGCTTTATCAGGC
TAAACGGGTGGTTAAGGGGGGTGAAGGATGTGCTGGTTTAGTGGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9367.64 Da        Isoelectric Point: 4.6119

>AT231287 WP_039324900.1 NZ_CP090588:4451740-4451991 [Pectobacterium aroidearum]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNSIESLKAGNGEERD
IIE

Download         Length: 252 bp

>AT231287 NZ_CP126323:c3569568-3569216 [Salmonella enterica subsp. enterica]
CCTGATAAAGCTGTTCGCGCAGCTCCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCTTCACC
GTCACGCCGCTCCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGTGGTCATGC
AGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGTATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCC
GGATGCTGGCTGATTGTGGAGCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCCTCTCCCCGGCCA
GTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2E5L4

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E625

References