Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 25740..26412 Replicon chromosome
Accession NZ_CP090587
Organism Pectobacterium aroidearum strain AK049

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L0Y26_RS00115 Protein ID WP_180779426.1
Coordinates 26026..26412 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L0Y26_RS00110 Protein ID WP_180779427.1
Coordinates 25740..26039 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y26_RS00090 (L0Y26_00090) 20975..21982 + 1008 WP_256554064.1 nucleoside hydrolase -
L0Y26_RS00095 (L0Y26_00095) 21982..22959 + 978 WP_012772765.1 ABC transporter permease -
L0Y26_RS00100 (L0Y26_00100) 22956..23864 + 909 WP_256554065.1 ABC transporter permease -
L0Y26_RS00105 (L0Y26_00105) 23904..25703 + 1800 WP_256554066.1 ABC transporter ATP-binding protein -
L0Y26_RS00110 (L0Y26_00110) 25740..26039 - 300 WP_180779427.1 XRE family transcriptional regulator Antitoxin
L0Y26_RS00115 (L0Y26_00115) 26026..26412 - 387 WP_180779426.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y26_RS00120 (L0Y26_00120) 26628..27125 + 498 WP_256554067.1 GNAT family N-acetyltransferase -
L0Y26_RS00125 (L0Y26_00125) 27325..27582 - 258 WP_225181734.1 DUF1471 domain-containing protein -
L0Y26_RS00130 (L0Y26_00130) 27755..28555 - 801 WP_194431341.1 aliphatic sulfonates ABC transporter ATP-binding protein -
L0Y26_RS00135 (L0Y26_00135) 28552..29346 - 795 WP_180779424.1 aliphatic sulfonate ABC transporter permease SsuC -
L0Y26_RS00140 (L0Y26_00140) 29357..30499 - 1143 WP_180779423.1 FMNH2-dependent alkanesulfonate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14834.84 Da        Isoelectric Point: 4.7331

>T231263 WP_180779426.1 NZ_CP090587:c26412-26026 [Pectobacterium aroidearum]
MEVYRLAWEIVTRALFDTWFDEQTETVQEEVLAHLGILEEDGPQLGRPQVDQIKGSQYKNMKELRVQVGGHPFRTFFAFD
RTRKAIVLCAGDKKGENEKLFYERMIKIADAEFTSHLISPEVKEDGDI

Download         Length: 387 bp

>T231263 NZ_CP126273:c85283-85023 [Curtobacterium sp. MCBD17_040]
GTGAGGTACGTCTGGGACGACGCTGCCTGGGCCGACTCCGAGTGGTGGCAACAGCAGGACCGGAAGATCGTCAAGCGGAT
CAACGGGTTGCTCCGTGACATCGCGCGCAACGGCAACGAGGGCATCGGCAAACCGGAGCCGCTCAAGCACGGGTTCCGTG
GGTACTGGTCCCGGCGCATCACGGACGAGCACCGTCTCGTGTACCGCGTCACGGACGACAGCGTCCTCATCGCGCAGTGC
CGGTACCACCACGACGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11082.10 Da        Isoelectric Point: 10.6442

>AT231263 WP_180779427.1 NZ_CP090587:c26039-25740 [Pectobacterium aroidearum]
MATFKEMMAKRSPESRARIEARTAEIRQEITLAKLREELNMSQTQLALALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPDGKRIALTL

Download         Length: 300 bp

>AT231263 NZ_CP126273:c85531-85280 [Curtobacterium sp. MCBD17_040]
ATGCGCATCCTCAGCTACTCGGAGACGCGTTCCCACTTCGCCGAGACCCTCAACGCCGTCACGGACGACCGCGAGGAGGT
CGTGGTCACGCGCGCGGGCCACGAATCGGTCGTGCTCGTGTCCCTCGACGACTACGAGTCCCTGAAGGAGACCGCCTACC
TGCTGAGGAACCCCGCGAACGCCCGGCGGCTGCTCGCCTCGATCGAGCGCCTGGAGCGCGGGGAGGGCACGGAGCGGGAC
CTGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References