Detailed information of TA system TA231201

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2720678..2720983
• Replicon: chromosome
• Accession: NZ_CP090558
• Organism: Enterococcus faecalis strain PCH555

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LZP99_RS13010
• Protein ID: WP_104866227.1
• Coordinates: 2720678..2720821 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2720753..2720983 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZP99_RS12995	2716394..2717026	-	633	WP_002358972.1	RloB family protein	-
LZP99_RS13000	2717035..2718330	-	1296	WP_104866226.1	ATP-binding protein	-
LZP99_RS13005	2718792..2720408	+	1617	WP_002365430.1	phosphatase PAP2/LCP family protein	-
LZP99_RS13010	2720678..2720821	+	144	WP_104866227.1	putative holin-like toxin	Toxin
-	2720753..2720983	-	231	-	-	Antitoxin
LZP99_RS13015	2721016..2725707	-	4692	WP_104866228.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5189.20 Da
• Isoelectric Point: 8.6389

>T231201 WP_104866227.1 NZ_CP090558:2720678-2720821 [Enterococcus faecalis]
MNVSTKIYEKRGLLSIAEALALMISFGSFIATLIFGILEAVKEENKK

Nucleotide

• Length: 144 bp

>T231201 NZ_CP126138:2107575-2107678 [Salmonella enterica subsp. enterica serovar Kottbus]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 231 bp

>AT231201 NZ_CP090558:c2720983-2720753 [Enterococcus faecalis]
AGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATAATGGTAATGAAAAGAGAGGTATGCGCCAACAT
ACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATTTATAAAAAATAACCGTGCTCGCTAAAGTTGAC
GGTTATTTTTTATTTTCTTCTTTAACAGCCTCTAGGATTCCGAAGATTAACGTTGCGATAAAAGAACCGAA

Structures

Antitoxin