Detailed information of TA system TA231196

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2541921..2542181
• Replicon: chromosome
• Accession: NZ_CP090558
• Organism: Enterococcus faecalis strain PCH555

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LZP99_RS12195
• Protein ID: WP_075551663.1
• Coordinates: 2542080..2542181 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2541921..2542131 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZP99_RS12170	2537605..2538558	-	954	WP_002365350.1	siderophore ABC transporter substrate-binding protein	-
LZP99_RS12175	2538597..2539352	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
LZP99_RS12180	2539349..2540314	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
LZP99_RS12185	2540311..2541258	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
LZP99_RS12190	2541443..2541895	+	453	WP_002354958.1	YueI family protein	-
-	2541921..2542131	+	211	-	-	Antitoxin
LZP99_RS12195	2542080..2542181	-	102	WP_075551663.1	putative holin-like toxin	Toxin
LZP99_RS12200	2542370..2544640	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
LZP99_RS12205	2544811..2545311	+	501	WP_002365352.1	cysteine hydrolase family protein	-
LZP99_RS12210	2545710..2546606	+	897	WP_002365354.1	YitT family protein	-
LZP99_RS12215	2546657..2547055	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T231196 WP_075551663.1 NZ_CP090558:c2542181-2542080 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T231196 NZ_CP126138:316711-317079 [Salmonella enterica subsp. enterica serovar Kottbus]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin

Nucleotide

• Length: 211 bp

>AT231196 NZ_CP090558:2541921-2542131 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGT
TATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin