Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1473410..1473977 Replicon chromosome
Accession NZ_CP090547
Organism Xylella fastidiosa subsp. sandyi strain OC8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LZ756_RS06970 Protein ID WP_004085174.1
Coordinates 1473696..1473977 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LZ756_RS06965 Protein ID WP_004085172.1
Coordinates 1473410..1473685 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ756_RS06935 (LZ756_06935) 1469310..1471184 + 1875 WP_020852856.1 phage major capsid protein -
LZ756_RS06940 (LZ756_06940) 1471202..1471462 + 261 WP_020852857.1 hypothetical protein -
LZ756_RS06945 (LZ756_06945) 1471462..1471785 + 324 WP_020852858.1 hypothetical protein -
LZ756_RS06950 (LZ756_06950) 1471782..1472303 + 522 WP_020850962.1 hypothetical protein -
LZ756_RS06955 (LZ756_06955) 1472279..1472821 + 543 WP_020850961.1 hypothetical protein -
LZ756_RS06960 (LZ756_06960) 1472818..1473405 + 588 WP_042836490.1 phage baseplate assembly protein V -
LZ756_RS06965 (LZ756_06965) 1473410..1473685 - 276 WP_004085172.1 HigA family addiction module antitoxin Antitoxin
LZ756_RS06970 (LZ756_06970) 1473696..1473977 - 282 WP_004085174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ756_RS06975 (LZ756_06975) 1474190..1474513 + 324 WP_011097934.1 GPW/gp25 family protein -
LZ756_RS06980 (LZ756_06980) 1474513..1475406 + 894 WP_020852724.1 baseplate J/gp47 family protein -
LZ756_RS06985 (LZ756_06985) 1475399..1475956 + 558 WP_020852723.1 phage tail protein I -
LZ756_RS06990 (LZ756_06990) 1475964..1477556 + 1593 WP_020852722.1 tail fiber domain-containing protein -
LZ756_RS06995 (LZ756_06995) 1477621..1478799 + 1179 WP_020852721.1 phage tail sheath family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1434171..1526858 92687


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 9.8829

>T231171 WP_004085174.1 NZ_CP090547:c1473977-1473696 [Xylella fastidiosa subsp. sandyi]
MIKSFRHKGIQQFFLVGSTAGIQTKHAAKLRIQLTALESAKRPEDMNAPGWKLHPLKGADLKGHWSIWVNGNYRLTFAFE
GEDAILVDYQDYH

Download         Length: 282 bp

>T231171 NZ_CP126100:c2252982-2252806 [Bacillus halotolerans]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10072.68 Da        Isoelectric Point: 10.2184

>AT231171 WP_004085172.1 NZ_CP090547:c1473685-1473410 [Xylella fastidiosa subsp. sandyi]
MKRMHNPAHPGEVLREYLGELTVTNAAAKLGVSRVALSRILNGTNGISADMALRLEDALGTSAEMWAAMQFKYDLWVASQ
QPRPKITRLHV

Download         Length: 276 bp

>AT231171 NZ_CP126100:2252765-2252865 [Bacillus halotolerans]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References