Detailed information of TA system TA231165

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4822907..4823509
• Replicon: chromosome
• Accession: NZ_CP090545
• Organism: Salmonella enterica strain 2017028-SE

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L0F57_RS23740
• Protein ID: WP_001159630.1
• Coordinates: 4823198..4823509 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L0F57_RS23735
• Protein ID: WP_000362050.1
• Coordinates: 4822907..4823197 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0F57_RS23720 (4820400)	4820400..4821302	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
L0F57_RS23725 (4821299)	4821299..4821934	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L0F57_RS23730 (4821931)	4821931..4822860	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L0F57_RS23735 (4822907)	4822907..4823197	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L0F57_RS23740 (4823198)	4823198..4823509	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L0F57_RS23745 (4823727)	4823727..4824656	+	930	WP_001127703.1	alpha/beta hydrolase	-
L0F57_RS23750 (4824742)	4824742..4825053	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
L0F57_RS23755 (4825050)	4825050..4825496	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
L0F57_RS23760 (4825511)	4825511..4826452	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L0F57_RS23765 (4826497)	4826497..4826934	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
L0F57_RS23770 (4826931)	4826931..4827803	-	873	WP_000921427.1	virulence factor BrkB family protein	-
L0F57_RS23775 (4827797)	4827797..4828396	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T231165 WP_001159630.1 NZ_CP090545:c4823509-4823198 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T231165 NZ_CP126098:281177-281527 [Peribacillus frigoritolerans]
ATTGTTGTTAAGCGTGGTGACGTATACTTCGCAGACCTTTCCCCGGTAGTCGGTTCAGAGCAGGGTGGAACCCGTCCGGT
ACTAATTTTACAAAACGATATTGGTAATCGCTTTAGTCCGACTGTGATCGTGGCAGCCATTACAGCTCAAATTCAAAAAG
CGAAATTGCCTACACATGTTGAGATTAATGCAAAAAAGTATGGATTCGAACGGGATTCCGTCATTTTATTAGAACAGATC
CGGACAATCGATAAGCAGCGTTTAACTGATAAAATTACGCATCTTGACGAACCGATGATGCAAAAAGTCAATGAAGCTTT
GCAAATAAGTTTAGGCCTCATTGAGTTTTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT231165 WP_000362050.1 NZ_CP090545:c4823197-4822907 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT231165 NZ_CP126098:280888-281169 [Peribacillus frigoritolerans]
GTGTCTGAATCCAGCGCAACAAGAGAGATATTAATTCGATTACCTCAAAATTTTTTAACAGAGTTAGACGGGTATGCGAG
TGAGGAAAATGTGAATCGCAGTGAATTTATTTATCGTGCCACAAAAATGTATCTTCGCGAACGTAAAAAGAAAGAGTTTC
GTGAATCGATGAAACGCGGTTATATTGAAATGGCGGCCATTAATTTAACGATTGCTTCTGAAGCCTTCCAAGCTGAATTC
GAGGCTGGTCATTGCGTTGAACGATTAGTTAGCGGAGGCTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64