Detailed information of TA system TA231140

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4766364..4766966
• Replicon: chromosome
• Accession: NZ_CP090541
• Organism: Salmonella enterica strain 2010112-SE

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L0F62_RS23300
• Protein ID: WP_001159630.1
• Coordinates: 4766655..4766966 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L0F62_RS23295
• Protein ID: WP_000362050.1
• Coordinates: 4766364..4766654 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0F62_RS23280 (4763857)	4763857..4764759	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
L0F62_RS23285 (4764756)	4764756..4765391	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L0F62_RS23290 (4765388)	4765388..4766317	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L0F62_RS23295 (4766364)	4766364..4766654	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L0F62_RS23300 (4766655)	4766655..4766966	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L0F62_RS23305 (4767184)	4767184..4768113	+	930	WP_001127703.1	alpha/beta hydrolase	-
L0F62_RS23310 (4768199)	4768199..4768510	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
L0F62_RS23315 (4768507)	4768507..4768953	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
L0F62_RS23320 (4768968)	4768968..4769909	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L0F62_RS23325 (4769954)	4769954..4770391	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
L0F62_RS23330 (4770388)	4770388..4771260	-	873	WP_000921427.1	virulence factor BrkB family protein	-
L0F62_RS23335 (4771254)	4771254..4771853	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T231140 WP_001159630.1 NZ_CP090541:c4766966-4766655 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T231140 NZ_CP126080:236818-237168 [Mesobacillus sp. AQ2]
TTGATTGTCAAACGTGGTGACGTCTATTTTGCAGACCTATCCCCAGTTGTTGGTTCGGAACAAGGCGGAGTGCGCCCTGT
CCTGGTCATCCAAAACGACATCGGGAATCGGTTCAGTCCCACAGTCATTATCGCAGCGATCACGGCACAGATCCAAAAAG
CCAAGCTTCCAACTCATGTAGAAATTGATGCGAAGCGGTACGGTTTTGAAAGAGATTCGGTCATATTATTGGAACAAATA
CGCACAATTGACAAACAGCGCCTAACCGATAAAATTACCCATCTCGATGACGAAATGATGGAAAAAGTGGATGAAGCCCT
TCAGGTAAGTTTAGGTCTTATTGAATTCTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT231140 WP_000362050.1 NZ_CP090541:c4766654-4766364 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT231140 NZ_CP126080:236532-236813 [Mesobacillus sp. AQ2]
GTGTCTGAATCCAGCGCAACAACTGAGATTTTGGTAAAGTTACCGCAGCATCTGTTGAGTGAACTAGATGGATTTGTTAA
GCAAGAAAACGTAAACCGCAGCGAATTTATTTATCAGGCAACAAAAATGTTTTTGCGTGAGAAGAAAAAGAGACAAATTC
GTGAATCCATGAGACGTGGCTATATGGAAATGGCCAAGATTAATCTAACCATTGCATCAGAAGCATTTCAAGCAGAATAC
GAGGCAGAACACACAGTTGAACGTCTAGTCAGCGGAGGATGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64