231132

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2451026..2451548 Replicon chromosome
Accession NZ_CP090541
Organism Salmonella enterica strain 2010112-SE

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag L0F62_RS12005 Protein ID WP_000221343.1
Coordinates 2451264..2451548 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag L0F62_RS12000 Protein ID WP_000885424.1
Coordinates 2451026..2451274 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F62_RS11975 (2446242) 2446242..2447708 + 1467 WP_000987828.1 hypothetical protein -
L0F62_RS11980 (2448516) 2448516..2449230 + 715 Protein_2346 helix-turn-helix domain-containing protein -
L0F62_RS11985 (2449286) 2449286..2450194 - 909 WP_010989018.1 hypothetical protein -
L0F62_RS11990 (2450337) 2450337..2450669 - 333 WP_000253154.1 DUF1493 family protein -
L0F62_RS11995 (2450659) 2450659..2450874 - 216 WP_000206207.1 hypothetical protein -
L0F62_RS12000 (2451026) 2451026..2451274 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L0F62_RS12005 (2451264) 2451264..2451548 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0F62_RS12010 (2451719) 2451719..2452108 + 390 WP_000194089.1 RidA family protein -
L0F62_RS12015 (2452160) 2452160..2453239 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
L0F62_RS12020 (2453432) 2453432..2453920 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
L0F62_RS12025 (2453965) 2453965..2455473 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2446245..2458330 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T231132 WP_000221343.1 NZ_CP090541:2451264-2451548 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T231132 NZ_CP126058:c4998964-4998617 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT231132 WP_000885424.1 NZ_CP090541:2451026-2451274 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT231132 NZ_CP126058:c4998617-4998318 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References