Detailed information of TA system TA231115

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4785095..4785697
• Replicon: chromosome
• Accession: NZ_CP090539
• Organism: Salmonella enterica strain 2016062-SE

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L0F59_RS23460
• Protein ID: WP_001159630.1
• Coordinates: 4785386..4785697 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L0F59_RS23455
• Protein ID: WP_000362050.1
• Coordinates: 4785095..4785385 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0F59_RS23440 (4782588)	4782588..4783490	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
L0F59_RS23445 (4783487)	4783487..4784122	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L0F59_RS23450 (4784119)	4784119..4785048	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L0F59_RS23455 (4785095)	4785095..4785385	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L0F59_RS23460 (4785386)	4785386..4785697	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L0F59_RS23465 (4785915)	4785915..4786844	+	930	WP_001127703.1	alpha/beta hydrolase	-
L0F59_RS23470 (4786930)	4786930..4787241	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
L0F59_RS23475 (4787238)	4787238..4787684	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
L0F59_RS23480 (4787699)	4787699..4788640	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L0F59_RS23485 (4788685)	4788685..4789122	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
L0F59_RS23490 (4789119)	4789119..4789991	-	873	WP_000921427.1	virulence factor BrkB family protein	-
L0F59_RS23495 (4789985)	4789985..4790584	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T231115 WP_001159630.1 NZ_CP090539:c4785697-4785386 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T231115 NZ_CP126055:54085-54384 [Pasteurella multocida]
ATGACAATTCGAATTAAAACAACTGAGCGCTTTGATTCTTGGCTGAGAAAGCTTAAAAATCCTCGCGCAAAGATGAAAAT
TAATGCGCGTATTAAGCGGTTACAATTCGGAAATTTTGGTGACTTAAAAACTGTTAATGATGGCATTTTTGAAATGCGTA
TAGATGAAGGGCAGGGGTATAGAATTTATTTAAAAAATAACAATAGTGTGGTGGTTATATTGTTGTGTGGTGGTGATAAA
TCAACACAAAACAAAGATATTAAATTAGCAAAACAAATTGCAGAAGAATTGGGGGTATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT231115 WP_000362050.1 NZ_CP090539:c4785385-4785095 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT231115 NZ_CP126055:54386-54682 [Pasteurella multocida]
ATGGAACAATTAAAAGATTTTGATATAGCAGAACATTTAACAACAGAAGAAGAAATCCGACTTTATCTTAATGAAATTTT
ACAAGAAGATAATATTGAATTGATTCTCTCCGCACTTGGCGATATTGCAAGGGCTAGAAATATAAGCCAAATCTCTCGAG
AAACTGGAATTAGTAGAGAAGGGCTTTATAAGGCATTATCTGGAAAAGGAAATCCGACCTTTGCAACAGTCCTTAAAGTG
ATGAAGGCTTTGAATTTACAGTTTGAAGTTAAAGTAAATAACGTTATTCATGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64