Detailed information of TA system TA231089

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4758711..4759313
• Replicon: chromosome
• Accession: NZ_CP090535
• Organism: Salmonella enterica strain 2016089-SE

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L0F58_RS23175
• Protein ID: WP_001159630.1
• Coordinates: 4759002..4759313 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L0F58_RS23170
• Protein ID: WP_000362050.1
• Coordinates: 4758711..4759001 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0F58_RS23155 (4756204)	4756204..4757106	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
L0F58_RS23160 (4757103)	4757103..4757738	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L0F58_RS23165 (4757735)	4757735..4758664	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L0F58_RS23170 (4758711)	4758711..4759001	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L0F58_RS23175 (4759002)	4759002..4759313	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L0F58_RS23180 (4759531)	4759531..4760460	+	930	WP_001127703.1	alpha/beta hydrolase	-
L0F58_RS23185 (4760546)	4760546..4760857	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
L0F58_RS23190 (4760854)	4760854..4761300	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
L0F58_RS23195 (4761315)	4761315..4762256	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L0F58_RS23200 (4762301)	4762301..4762738	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
L0F58_RS23205 (4762735)	4762735..4763607	-	873	WP_000921427.1	virulence factor BrkB family protein	-
L0F58_RS23210 (4763601)	4763601..4764200	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T231089 WP_001159630.1 NZ_CP090535:c4759313-4759002 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T231089 NZ_CP125957:2393445-2393699 [Pseudomonas sp. G2-4]
TTGGAGCGTTGTCGTCGTTTCCTATTGGAAAAAGACCCGCAGGTGACGCGTAGGGCTGCTCAAACCATTGAGCAGCAGTT
AATGCGCTTGGAAACCGATCCCCATGTCGGCCGACCTTATGACGAGATGCCTGAGTTGCGAGAGCTGGTCATTGCTTTTG
GTGATGCGGGCTATGTCGCACTTTATCGTTTTGCTCCCACAGAAGAAGCCGTATACGTATTGGCGTTTCGGCATCAGAGG
GAAGCAGGTTACTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT231089 WP_000362050.1 NZ_CP090535:c4759001-4758711 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT231089 NZ_CP125957:2393146-2393418 [Pseudomonas sp. G2-4]
ATGGCAACGTCAATCAAAATCGATGAGGATTTGAAGTACCGCATCCAGCAATTGGCGAGTGCCCGGCAACGTTCGGCTCA
CTGGATCATGCGTGAAGCCCTCTCGCAGTATGTCGTGCGGGAGGAGGCGCGGGAAAGTTTCAAGCAGGAGGCGCTGGCTT
CGTGGAAGGCTTACCAGGAAACAGGCCAGCACCTGACTGGGGCCGAGACCCGAGACTGGCTTAAAACCTGGGGAACCGAG
GAAGAGTCGGAGCTTCCCACGTGCCACGACTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64