231081

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2466988..2467510 Replicon chromosome
Accession NZ_CP090535
Organism Salmonella enterica strain 2016089-SE

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag L0F58_RS12095 Protein ID WP_000221343.1
Coordinates 2467226..2467510 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag L0F58_RS12090 Protein ID WP_000885424.1
Coordinates 2466988..2467236 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F58_RS12065 (2462204) 2462204..2463670 + 1467 WP_000987828.1 hypothetical protein -
L0F58_RS12070 (2464478) 2464478..2465192 + 715 Protein_2366 helix-turn-helix domain-containing protein -
L0F58_RS12075 (2465248) 2465248..2466156 - 909 WP_010989018.1 hypothetical protein -
L0F58_RS12080 (2466299) 2466299..2466631 - 333 WP_000253154.1 DUF1493 family protein -
L0F58_RS12085 (2466621) 2466621..2466836 - 216 WP_000206207.1 hypothetical protein -
L0F58_RS12090 (2466988) 2466988..2467236 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L0F58_RS12095 (2467226) 2467226..2467510 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0F58_RS12100 (2467681) 2467681..2468070 + 390 WP_000194089.1 RidA family protein -
L0F58_RS12105 (2468122) 2468122..2469201 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
L0F58_RS12110 (2469394) 2469394..2469882 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
L0F58_RS12115 (2469927) 2469927..2471435 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2462207..2474292 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T231081 WP_000221343.1 NZ_CP090535:2467226-2467510 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T231081 NZ_CP125948:c8532-8194 [Comamonas sp. ZM22]
ATGAAAGCCGTCTTCGTTGAATTGCCTGCCTTCGAGCGAAACAGAGCCACCTACCTCAACGATGACGAGTTCAAGGAGTT
CCAAGAGCGCTTGCTCAAGAACCCTGAAGCGGGCGACATGATCGAAGGCACCGGCGGGCTGCGCAAGGTGCGCCATGGTG
ATCCACGCAGAGGCAAAGGAACTCGCGGCGGGTTACGGGTCATCTACTACTGGTGGAGCGGTGGTCCGCAGTTTTGGCTC
TTCACTCTGTACGACAAGGACGAGTTAGAGAACCTGACACCAAAGCAGAAAGCGATCCTGAAGCAGCTTTTGAAAACCGA
ATTGGAGGCCAGAAAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT231081 WP_000885424.1 NZ_CP090535:2466988-2467236 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT231081 NZ_CP125948:c8197-7883 [Comamonas sp. ZM22]
ATGACCAAGCGTGATCTCTTTGCAGAACTCAGCGAAGGCTTTGATGCACTAGCGAGTGCACGTGCAGGAAAGCGCACGCT
GCGAACCCACGAGGTGGAGCTGAAGCCTGAAGTCACCATCACCTCTGCCGAACTCAAGTCGATTCGGGAACGTTTGAATC
TTTCTAGGCCCGTCTTCGCCAGCTACCTGAGGACAAAAACCCGAACCTTGGAGAATTGGGAGCAAGGCAGGGCTGCGCCG
AATGCGCAAGCTGCCTTGCTGATCCGGCTGGTGGAGAAGTATCCCGACACGGTTTCTCGCCTCGCAGCGGTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References