Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4781791..4782545 Replicon chromosome
Accession NZ_CP090529
Organism Salmonella enterica strain 2008079-SE

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag L0F60_RS23315 Protein ID WP_000558166.1
Coordinates 4781791..4782102 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L0F60_RS23320 Protein ID WP_001259011.1
Coordinates 4782099..4782545 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F60_RS23285 (4777449) 4777449..4778351 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
L0F60_RS23290 (4778348) 4778348..4778983 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
L0F60_RS23295 (4778980) 4778980..4779909 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
L0F60_RS23300 (4779956) 4779956..4780246 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
L0F60_RS23305 (4780247) 4780247..4780558 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
L0F60_RS23310 (4780776) 4780776..4781705 + 930 WP_001127703.1 alpha/beta hydrolase -
L0F60_RS23315 (4781791) 4781791..4782102 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
L0F60_RS23320 (4782099) 4782099..4782545 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
L0F60_RS23325 (4782560) 4782560..4783501 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
L0F60_RS23330 (4783546) 4783546..4783983 - 438 WP_131166381.1 D-aminoacyl-tRNA deacylase -
L0F60_RS23335 (4783980) 4783980..4784852 - 873 WP_000921427.1 virulence factor BrkB family protein -
L0F60_RS23340 (4784846) 4784846..4785445 - 600 WP_000965695.1 glucose-1-phosphatase -
L0F60_RS23345 (4785636) 4785636..4786439 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
L0F60_RS23350 (4786473) 4786473..4787369 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T231036 WP_000558166.1 NZ_CP090529:4781791-4782102 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T231036 NZ_CP125897:c2199258-2199154 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT231036 WP_001259011.1 NZ_CP090529:4782099-4782545 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT231036 NZ_CP125897:2199060-2199098 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References