231027

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2487081..2487603 Replicon chromosome
Accession NZ_CP090529
Organism Salmonella enterica strain 2008079-SE

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag L0F60_RS12225 Protein ID WP_000221343.1
Coordinates 2487319..2487603 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag L0F60_RS12220 Protein ID WP_000885424.1
Coordinates 2487081..2487329 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F60_RS12195 (2482297) 2482297..2483763 + 1467 WP_000987828.1 hypothetical protein -
L0F60_RS12200 (2484571) 2484571..2485285 + 715 Protein_2395 helix-turn-helix domain-containing protein -
L0F60_RS12205 (2485341) 2485341..2486249 - 909 WP_010989018.1 hypothetical protein -
L0F60_RS12210 (2486392) 2486392..2486724 - 333 WP_000253154.1 DUF1493 family protein -
L0F60_RS12215 (2486714) 2486714..2486929 - 216 WP_000206207.1 hypothetical protein -
L0F60_RS12220 (2487081) 2487081..2487329 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L0F60_RS12225 (2487319) 2487319..2487603 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0F60_RS12230 (2487774) 2487774..2488163 + 390 WP_000194089.1 RidA family protein -
L0F60_RS12235 (2488215) 2488215..2489294 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
L0F60_RS12240 (2489487) 2489487..2489975 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
L0F60_RS12245 (2490020) 2490020..2491528 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2482300..2494385 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T231027 WP_000221343.1 NZ_CP090529:2487319-2487603 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T231027 NZ_CP125895:c2430361-2430254 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT231027 WP_000885424.1 NZ_CP090529:2487081-2487329 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT231027 NZ_CP125895:2430177-2430237 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References