Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1222032..1222669 Replicon chromosome
Accession NZ_CP090513
Organism Xylella fastidiosa subsp. multiplex strain Red Oak 8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LZ751_RS05305 Protein ID WP_004085174.1
Coordinates 1222388..1222669 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LZ751_RS05300 Protein ID WP_004087025.1
Coordinates 1222032..1222331 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ751_RS05275 (LZ751_05275) 1218250..1219842 - 1593 WP_012337641.1 tail fiber domain-containing protein -
LZ751_RS05280 (LZ751_05280) 1219850..1220407 - 558 WP_012337642.1 phage tail protein I -
LZ751_RS05285 (LZ751_05285) 1220400..1221293 - 894 WP_012337643.1 baseplate J/gp47 family protein -
LZ751_RS05290 (LZ751_05290) 1221293..1221697 - 405 WP_012337644.1 GPW/gp25 family protein -
LZ751_RS05295 (LZ751_05295) 1221739..1222020 + 282 WP_004087027.1 XRE family transcriptional regulator -
LZ751_RS05300 (LZ751_05300) 1222032..1222331 + 300 WP_004087025.1 HigA family addiction module antitoxin Antitoxin
LZ751_RS05305 (LZ751_05305) 1222388..1222669 + 282 WP_004085174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ751_RS05310 (LZ751_05310) 1222680..1222955 + 276 WP_012337645.1 HigA family addiction module antitoxin -
LZ751_RS05315 (LZ751_05315) 1222960..1223547 - 588 WP_012337646.1 phage baseplate assembly protein V -
LZ751_RS05320 (LZ751_05320) 1223544..1224086 - 543 WP_012337647.1 hypothetical protein -
LZ751_RS05325 (LZ751_05325) 1224062..1224583 - 522 WP_012337648.1 hypothetical protein -
LZ751_RS05330 (LZ751_05330) 1224580..1224903 - 324 WP_012337649.1 hypothetical protein -
LZ751_RS05335 (LZ751_05335) 1224903..1225163 - 261 WP_012337650.1 hypothetical protein -
LZ751_RS05340 (LZ751_05340) 1225181..1227055 - 1875 WP_012337651.1 phage major capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1212096..1263041 50945


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 9.8829

>T230977 WP_004085174.1 NZ_CP090513:1222388-1222669 [Xylella fastidiosa subsp. multiplex]
MIKSFRHKGIQQFFLVGSTAGIQTKHAAKLRIQLTALESAKRPEDMNAPGWKLHPLKGADLKGHWSIWVNGNYRLTFAFE
GEDAILVDYQDYH

Download         Length: 282 bp

>T230977 NZ_CP125762:c2024844-2024728 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11022.77 Da        Isoelectric Point: 9.0879

>AT230977 WP_004087025.1 NZ_CP090513:1222032-1222331 [Xylella fastidiosa subsp. multiplex]
MTMSKTLPPIHPGEILREEFMVPLGLSSNALAKAIGVTAARINEIVRERRGITAETALRLARYFGTDPQSWLNLEQHYAL
ECAKRDLGDALSRIHPRVA

Download         Length: 300 bp

>AT230977 NZ_CP125762:2024554-2024733 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References