Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 459978..460615 Replicon chromosome
Accession NZ_CP090513
Organism Xylella fastidiosa subsp. multiplex strain Red Oak 8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LZ751_RS01880 Protein ID WP_004085174.1
Coordinates 460334..460615 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LZ751_RS01875 Protein ID WP_004087025.1
Coordinates 459978..460277 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ751_RS01850 (LZ751_01850) 456196..457788 - 1593 WP_012337641.1 tail fiber domain-containing protein -
LZ751_RS01855 (LZ751_01855) 457796..458353 - 558 WP_012337642.1 phage tail protein I -
LZ751_RS01860 (LZ751_01860) 458346..459239 - 894 WP_012337643.1 baseplate J/gp47 family protein -
LZ751_RS01865 (LZ751_01865) 459239..459643 - 405 WP_012337644.1 GPW/gp25 family protein -
LZ751_RS01870 (LZ751_01870) 459685..459966 + 282 WP_004087027.1 XRE family transcriptional regulator -
LZ751_RS01875 (LZ751_01875) 459978..460277 + 300 WP_004087025.1 HigA family addiction module antitoxin Antitoxin
LZ751_RS01880 (LZ751_01880) 460334..460615 + 282 WP_004085174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ751_RS01885 (LZ751_01885) 460626..460901 + 276 WP_012337645.1 HigA family addiction module antitoxin -
LZ751_RS01890 (LZ751_01890) 460906..461493 - 588 WP_012337646.1 phage baseplate assembly protein V -
LZ751_RS01895 (LZ751_01895) 461490..462032 - 543 WP_012337647.1 hypothetical protein -
LZ751_RS01900 (LZ751_01900) 462008..462529 - 522 WP_012337648.1 hypothetical protein -
LZ751_RS01905 (LZ751_01905) 462526..462849 - 324 WP_012337649.1 hypothetical protein -
LZ751_RS01910 (LZ751_01910) 462849..463109 - 261 WP_012337650.1 hypothetical protein -
LZ751_RS01915 (LZ751_01915) 463127..463927 - 801 WP_234556088.1 phage major capsid protein -
LZ751_RS01920 (LZ751_01920) 463996..465000 - 1005 WP_234556080.1 HK97 family phage prohead protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 446882..481254 34372


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 9.8829

>T230973 WP_004085174.1 NZ_CP090513:460334-460615 [Xylella fastidiosa subsp. multiplex]
MIKSFRHKGIQQFFLVGSTAGIQTKHAAKLRIQLTALESAKRPEDMNAPGWKLHPLKGADLKGHWSIWVNGNYRLTFAFE
GEDAILVDYQDYH

Download         Length: 282 bp

>T230973 NZ_CP125736:207515-207664 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11022.77 Da        Isoelectric Point: 9.0879

>AT230973 WP_004087025.1 NZ_CP090513:459978-460277 [Xylella fastidiosa subsp. multiplex]
MTMSKTLPPIHPGEILREEFMVPLGLSSNALAKAIGVTAARINEIVRERRGITAETALRLARYFGTDPQSWLNLEQHYAL
ECAKRDLGDALSRIHPRVA

Download         Length: 300 bp

>AT230973 NZ_CP125736:c207471-207410 [Klebsiella pneumoniae]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References