Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1772240..1772807 Replicon chromosome
Accession NZ_CP090506
Organism Xylella fastidiosa subsp. morus strain Riv19

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LZ757_RS08425 Protein ID WP_004085174.1
Coordinates 1772240..1772521 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LZ757_RS08430 Protein ID WP_004085172.1
Coordinates 1772532..1772807 (+) Length 92 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ757_RS08400 (LZ757_08400) 1767418..1768596 - 1179 WP_027700434.1 phage tail sheath family protein -
LZ757_RS08405 (LZ757_08405) 1768661..1770253 - 1593 WP_040123119.1 tail fiber domain-containing protein -
LZ757_RS08410 (LZ757_08410) 1770261..1770818 - 558 WP_027700436.1 phage tail protein I -
LZ757_RS08415 (LZ757_08415) 1770811..1771704 - 894 WP_234056296.1 baseplate J/gp47 family protein -
LZ757_RS08420 (LZ757_08420) 1771704..1772027 - 324 WP_228304176.1 GPW/gp25 family protein -
LZ757_RS08425 (LZ757_08425) 1772240..1772521 + 282 WP_004085174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ757_RS08430 (LZ757_08430) 1772532..1772807 + 276 WP_004085172.1 HigA family addiction module antitoxin Antitoxin
LZ757_RS08435 (LZ757_08435) 1772895..1773197 + 303 WP_038230541.1 type II toxin-antitoxin system MqsR family toxin -
LZ757_RS08440 (LZ757_08440) 1773200..1773601 + 402 WP_004090697.1 type II toxin-antitoxin system MqsA family antitoxin -
LZ757_RS08445 (LZ757_08445) 1773670..1774257 - 588 WP_040123117.1 phage baseplate assembly protein V -
LZ757_RS08450 (LZ757_08450) 1774254..1774796 - 543 WP_038230164.1 hypothetical protein -
LZ757_RS08455 (LZ757_08455) 1774772..1775293 - 522 WP_038230165.1 hypothetical protein -
LZ757_RS08460 (LZ757_08460) 1775290..1775613 - 324 WP_027700441.1 hypothetical protein -
LZ757_RS08465 (LZ757_08465) 1775613..1775873 - 261 WP_027700442.1 hypothetical protein -
LZ757_RS08470 (LZ757_08470) 1775891..1777765 - 1875 WP_038230171.1 phage major capsid protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1752103..1802800 50697


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-93)

Antitoxin

(15-64)


Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 9.8829

>T230932 WP_004085174.1 NZ_CP090506:1772240-1772521 [Xylella fastidiosa subsp. morus]
MIKSFRHKGIQQFFLVGSTAGIQTKHAAKLRIQLTALESAKRPEDMNAPGWKLHPLKGADLKGHWSIWVNGNYRLTFAFE
GEDAILVDYQDYH

Download         Length: 282 bp

>T230932 NZ_CP125721:c25280-25014 [Staphylococcus casei]
ATGGATAATTACAGTATTGCTATTAAAAATTCAGCAAAATCTGATTTAAAGAAAATTAAACAATCACAGTTGAAAACACA
ATTCTTAAAAATTGTAGACACGTTAAAAGAAGACCCTTATTTTCCGAGCCAATCTTTTGAAAAGTTGCAACCTAAACACT
TAGAGCGCTATTCAAGAAGAATAAACCATCAACATAGAGTTGTTTACACAGTTGATGAAGATGATAAGAACGTTTTTATC
CTTTCTGCATGGTCACATTATGAATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10072.68 Da        Isoelectric Point: 10.2184

>AT230932 WP_004085172.1 NZ_CP090506:1772532-1772807 [Xylella fastidiosa subsp. morus]
MKRMHNPAHPGEVLREYLGELTVTNAAAKLGVSRVALSRILNGTNGISADMALRLEDALGTSAEMWAAMQFKYDLWVASQ
QPRPKITRLHV

Download         Length: 276 bp

>AT230932 NZ_CP125721:c25538-25281 [Staphylococcus casei]
ATGAATATTAAAACGCCTACCAATGCTAGAAAAGAATTCTATGAATTACTTAAACAAGTTAATGAGAGCCACGAACCCGT
TATTATAAGCAGTTCTAAGAGTGAAAATAACGCCGTAATCATAAGCCAAAAAGATTGGGATAGTATTCAAGAAACATTAT
ATCTTGAAACAACAGGTACTATGGATAAAGTACGAGAACGTGAAAAGGATAACAGTGGTTACGCTAATATTGATGATTTA
GACTGGGATAATCTCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References