Detailed information of TA system TA230918

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1773072..1773778
• Replicon: chromosome
• Accession: NZ_CP090504
• Organism: Xylella fastidiosa subsp. morus strain Riv25

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A060HKF7
• Locus tag: LZ755_RS08455
• Protein ID: WP_038230541.1
• Coordinates: 1773072..1773374 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q87EE1
• Locus tag: LZ755_RS08460
• Protein ID: WP_004090697.1
• Coordinates: 1773377..1773778 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ755_RS08425 (LZ755_08425)	1768838..1770430	-	1593	WP_040123119.1	tail fiber domain-containing protein	-
LZ755_RS08430 (LZ755_08430)	1770438..1770995	-	558	WP_027700436.1	phage tail protein I	-
LZ755_RS08435 (LZ755_08435)	1770988..1771881	-	894	WP_234056296.1	baseplate J/gp47 family protein	-
LZ755_RS08440 (LZ755_08440)	1771881..1772204	-	324	WP_228304176.1	GPW/gp25 family protein	-
LZ755_RS08445 (LZ755_08445)	1772417..1772698	+	282	WP_004085174.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LZ755_RS08450 (LZ755_08450)	1772709..1772984	+	276	WP_004085172.1	HigA family addiction module antitoxin	-
LZ755_RS08455 (LZ755_08455)	1773072..1773374	+	303	WP_038230541.1	type II toxin-antitoxin system MqsR family toxin	Toxin
LZ755_RS08460 (LZ755_08460)	1773377..1773778	+	402	WP_004090697.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
LZ755_RS08465 (LZ755_08465)	1773847..1774434	-	588	WP_040123117.1	phage baseplate assembly protein V	-
LZ755_RS08470 (LZ755_08470)	1774431..1774973	-	543	WP_038230164.1	hypothetical protein	-
LZ755_RS08475 (LZ755_08475)	1774949..1775470	-	522	WP_038230165.1	hypothetical protein	-
LZ755_RS12285	1775467..1775595	-	129	WP_267964582.1	hypothetical protein	-
LZ755_RS08480 (LZ755_08480)	1775570..1775791	-	222	WP_234553082.1	hypothetical protein	-
LZ755_RS08485 (LZ755_08485)	1775791..1776051	-	261	WP_027700442.1	hypothetical protein	-
LZ755_RS08490 (LZ755_08490)	1776069..1777943	-	1875	WP_038230171.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1752280..1802985	50705

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10972.77 Da
• Isoelectric Point: 8.0251

>T230918 WP_038230541.1 NZ_CP090504:1773072-1773374 [Xylella fastidiosa subsp. morus]
MEKGTPHYKLPVVKALVKAGKVRATATAYQGARELGIKDLTGMCAVVLALTSADFYKSMTTYTDHTLFQDVYHAKTASGD
EVYLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 303 bp

>T230918 NZ_CP125660:c2219571-2219395 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14944.02 Da
• Isoelectric Point: 7.1650

>AT230918 WP_004090697.1 NZ_CP090504:1773377-1773778 [Xylella fastidiosa subsp. morus]
MRCPCCGAAELIHDTRDMLYTYKSETTSIPTVTGDFCPACGEVVLDREHGDRYSELVGLFQRQVNSAYVDPGYITKVRRK
LDLDQRQAAELFGGGVNAFSRYENGKTKPPLSLVKLFKLLDRHPDLLNEVKSS

Nucleotide

• Length: 402 bp

>AT230918 NZ_CP125660:2219512-2219612 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTACGATACCCATTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT

Structures

Toxin

• AlphaFold DB: A0A060HKF7

Antitoxin

• AlphaFold DB: Q87EE1