Detailed information of TA system TA230903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 682621..683213
• Replicon: chromosome
• Accession: NZ_CP090489
• Organism: Photobacterium damselae subsp. damselae strain AS-15-3942-8

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: IHC91_RS03440
• Protein ID: WP_176848313.1
• Coordinates: 682893..683213 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IHC91_RS03435
• Protein ID: WP_237029761.1
• Coordinates: 682621..682896 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHC91_RS03405 (IHC91_03405)	678105..678536	-	432	WP_068968925.1	DUF2069 domain-containing protein	-
IHC91_RS03410 (IHC91_03410)	678576..679151	-	576	WP_068946190.1	NAD(P)H:quinone oxidoreductase	-
IHC91_RS03415 (IHC91_03415)	679152..679502	-	351	WP_237029759.1	arsenate reductase (glutaredoxin)	-
IHC91_RS03420 (IHC91_03420)	679511..680974	-	1464	WP_237029760.1	M48 family metallopeptidase	-
IHC91_RS03425 (IHC91_03425)	681183..681407	+	225	WP_157132356.1	sulfurtransferase TusA family protein	-
IHC91_RS03430 (IHC91_03430)	681410..682489	+	1080	WP_065171568.1	AI-2E family transporter	-
IHC91_RS03435 (IHC91_03435)	682621..682896	-	276	WP_237029761.1	helix-turn-helix transcriptional regulator	Antitoxin
IHC91_RS03440 (IHC91_03440)	682893..683213	-	321	WP_176848313.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IHC91_RS03445 (IHC91_03445)	683772..685559	-	1788	WP_237029762.1	DUF2326 domain-containing protein	-
IHC91_RS03450 (IHC91_03450)	685556..685795	-	240	WP_237029763.1	hypothetical protein	-
IHC91_RS03455 (IHC91_03455)	685785..686795	-	1011	WP_237029764.1	restriction endonuclease	-
IHC91_RS03460 (IHC91_03460)	687103..687570	-	468	WP_237029765.1	thioredoxin-dependent thiol peroxidase	-
IHC91_RS03465 (IHC91_03465)	687598..688155	-	558	WP_065171574.1	ACT domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12040.29 Da
• Isoelectric Point: 9.9834

>T230903 WP_176848313.1 NZ_CP090489:c683213-682893 [Photobacterium damselae subsp. damselae]
MAWKVDFYSGVEDEILAMPPKIQARMIKLLELIELHGANLGPPHTESMGDGLFEIRAKAQEGIGRGLFCYLKGQHVYVLR
AFVKKTNKTPKKEIEIAKKRMKEVTL

Nucleotide

• Length: 321 bp

>T230903 NZ_CP125655:c1266649-1266230 [Cellulomonas sp. ES6]
ATGATCGTGCTGGACACCCACGTCATCTCGGAGGTCTTCCGGCCCGAGCCCGAGGCGCGGGTCGTGGCCTGGCTCGAAGG
GCTGACCGGGGAGGTCGCGATCGCTGCCGTGACGCTCGCCGAGCTGCTCGCCGGGGTCCGTCGGCTCCCCGACGGGCAGC
GCCGCACCGCGCTCGCCGGGATGCTCCACGACGCGTTGGAGCCCTATCGCGCGACCCGGGCCATCCTGCCGTTCGACGTG
GCAGCCGCCGAGCAGTACGCGGACGTCCTCGCCGCGCGCGAGCGGGCGGGTCGGCCGATCCACACCGCTGACGCCCAGAT
CGCGGCGATCTGCCTGGCGCACGGAGCCACGTGCGCCACCCGGAACGTCCGGGACTTCGACGGCACCGGTGTGGATCTCG
TCAACCCGTGGACCGCGTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9974.46 Da
• Isoelectric Point: 9.0008

>AT230903 WP_237029761.1 NZ_CP090489:c682896-682621 [Photobacterium damselae subsp. damselae]
MSLSELKRKALQNPEVKEAYDGLSAEFELISSLISMREQSGLTQDEVAAKMGTKAPNISRLESGRSNPSLKTLISYAQAC
GFKLNLGFKHI

Nucleotide

• Length: 276 bp

>AT230903 NZ_CP125655:c1266879-1266646 [Cellulomonas sp. ES6]
ATGTCCACCATCGTCGTCCGCGGGCTCGACGAGTCCGTGAAGCAGCAGCTCGCCGCCCAGGCCAAGGAGCACGGCCGGTC
CATGGAGGCTGAGGCGCGCGACATCCTCACCAGGGCTGCTCGCCGCCCCCACATCGGTGTGGCCCTCCTCCGGGCGGCCC
GTCAGGTCGGTGGCGTCGAGGGCCTCGTCGTGCCGGAGCGCAGCGACGACGCCCGGGCGGTGGACCTCGAATGA