Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3938451..3939048 Replicon chromosome
Accession NZ_CP090468
Organism Klebsiella pneumoniae strain kp7450

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag LZ687_RS19020 Protein ID WP_004142563.1
Coordinates 3938731..3939048 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag LZ687_RS19015 Protein ID WP_004142561.1
Coordinates 3938451..3938738 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ687_RS18985 (3934531) 3934531..3934779 + 249 WP_020325243.1 DUF1158 domain-containing protein -
LZ687_RS18990 (3934797) 3934797..3935138 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
LZ687_RS18995 (3935169) 3935169..3936284 - 1116 WP_020325248.1 MBL fold metallo-hydrolase -
LZ687_RS19000 (3936464) 3936464..3937045 + 582 WP_020325240.1 TetR/AcrR family transcriptional regulator -
LZ687_RS19005 (3937045) 3937045..3937413 + 369 WP_020325252.1 MmcQ/YjbR family DNA-binding protein -
LZ687_RS19010 (3937533) 3937533..3938186 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
LZ687_RS19015 (3938451) 3938451..3938738 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
LZ687_RS19020 (3938731) 3938731..3939048 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ687_RS19025 (3939233) 3939233..3940276 - 1044 WP_020325241.1 DUF2157 domain-containing protein -
LZ687_RS19030 (3940946) 3940946..3941812 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
LZ687_RS19035 (3941921) 3941921..3943348 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T230870 WP_004142563.1 NZ_CP090468:c3939048-3938731 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T230870 NZ_CP125620:2915140-2915580 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT230870 WP_004142561.1 NZ_CP090468:c3938738-3938451 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT230870 NZ_CP125620:2914866-2915153 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References