Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 743955..744730 Replicon chromosome
Accession NZ_CP090462
Organism Klebsiella pneumoniae strain kp5152

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag LZ688_RS03715 Protein ID WP_004150910.1
Coordinates 744245..744730 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag LZ688_RS03710 Protein ID WP_004150912.1
Coordinates 743955..744248 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ688_RS03690 (LZ688_03690) 739163..739765 - 603 WP_062954968.1 short chain dehydrogenase -
LZ688_RS03695 (LZ688_03695) 739863..740774 + 912 WP_004188550.1 LysR family transcriptional regulator -
LZ688_RS03700 (LZ688_03700) 740775..741923 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
LZ688_RS03705 (LZ688_03705) 741934..743310 - 1377 WP_004217775.1 cystathionine beta-synthase -
LZ688_RS03710 (LZ688_03710) 743955..744248 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
LZ688_RS03715 (LZ688_03715) 744245..744730 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
LZ688_RS03720 (LZ688_03720) 745434..746027 + 594 WP_004188553.1 hypothetical protein -
LZ688_RS03725 (LZ688_03725) 746124..746340 + 217 Protein_732 transposase -
LZ688_RS03730 (LZ688_03730) 746946..747818 + 873 WP_004188557.1 ParA family protein -
LZ688_RS03735 (LZ688_03735) 747818..748201 + 384 WP_004150906.1 hypothetical protein -
LZ688_RS03740 (LZ688_03740) 748194..749561 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 746124..746276 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T230830 WP_004150910.1 NZ_CP090462:744245-744730 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T230830 NZ_CP125620:c640485-640072 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT230830 WP_004150912.1 NZ_CP090462:743955-744248 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT230830 NZ_CP125620:c640748-640482 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References