Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1897243..1897745 | Replicon | chromosome |
| Accession | NZ_CP090456 | ||
| Organism | Escherichia coli strain B379 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | LZ684_RS08970 | Protein ID | WP_000767829.1 |
| Coordinates | 1897491..1897745 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | LZ684_RS08965 | Protein ID | WP_001259255.1 |
| Coordinates | 1897243..1897494 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ684_RS08940 (1892421) | 1892421..1893488 | - | 1068 | WP_001618671.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| LZ684_RS08945 (1893488) | 1893488..1894558 | - | 1071 | WP_000108980.1 | histidinol-phosphate transaminase | - |
| LZ684_RS08950 (1894555) | 1894555..1895859 | - | 1305 | WP_001499066.1 | histidinol dehydrogenase | - |
| LZ684_RS08955 (1895865) | 1895865..1896764 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| LZ684_RS08960 (1896910) | 1896910..1896960 | - | 51 | WP_001368802.1 | his operon leader peptide | - |
| LZ684_RS08965 (1897243) | 1897243..1897494 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| LZ684_RS08970 (1897491) | 1897491..1897745 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| LZ684_RS08975 (1897828) | 1897828..1898652 | + | 825 | WP_001618670.1 | SDR family oxidoreductase | - |
| LZ684_RS08980 (1898698) | 1898698..1899627 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| LZ684_RS08985 (1899842) | 1899842..1899904 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| LZ684_RS08990 (1899894) | 1899894..1901252 | + | 1359 | WP_001618669.1 | putrescine/proton symporter PlaP | - |
| LZ684_RS08995 (1901431) | 1901431..1902489 | + | 1059 | WP_024193414.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| LZ684_RS09000 (1902503) | 1902503..1902730 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T230805 WP_000767829.1 NZ_CP090456:1897491-1897745 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T230805 NZ_CP125385:28600-29283 [Campylobacter jejuni]
ATGATTGATAAAGTTTTGAAATTTTTAGATGATGGTATTCCTAAAAATGATTTTGACAGACAACTTTTAGCTTCTAATTT
AGTAGGCGCAACAAATTTAATAGAGTTAAATAAACGAGAAAGAGAAATTACATTAAAAAAACAATTAAAACTACAACTCA
ATCCCATTAAAGGCAATTTCGATTATCAGCATTTAAAAGATATACATAAAGCACTTTTTGAAGATGTTTATACTTGGGCA
GGACAAGATAGAATGCAAATGGGACTAAAAGAAAAATTTGCAAAATATGCACCCAATGGAGCAATTATTAATTTTGTTCC
TGGAAAAGAGTTAGATAAATACTCTAAAATAATTTTTGATGAACTTGCAAAAAATAACTATCTAAAAAACTCCAAAGATC
TAAATCATTTTGCAAAAAATTTAGCAAAATTTATGGGCGAAATCAATGCTTTACACCCTTTTAGAGAAGGTAACGGCAGA
ACTCAAAGAATATTTTTAAACGAGTTGGCTAAAAATGCAGGTTATAAACTTGATTTAAATTTAATTTCTAAGCATAAAAT
GATACATGCTTGTGCAGAAGCTTCACAATTAAAACCTGGAAGATTGGAGGCTTTAATTAAAGACAATCTAAAAAACTTTA
GACAAAATTTAGATTTGGAGCAAAATAAAGGAATATCATTATAA
ATGATTGATAAAGTTTTGAAATTTTTAGATGATGGTATTCCTAAAAATGATTTTGACAGACAACTTTTAGCTTCTAATTT
AGTAGGCGCAACAAATTTAATAGAGTTAAATAAACGAGAAAGAGAAATTACATTAAAAAAACAATTAAAACTACAACTCA
ATCCCATTAAAGGCAATTTCGATTATCAGCATTTAAAAGATATACATAAAGCACTTTTTGAAGATGTTTATACTTGGGCA
GGACAAGATAGAATGCAAATGGGACTAAAAGAAAAATTTGCAAAATATGCACCCAATGGAGCAATTATTAATTTTGTTCC
TGGAAAAGAGTTAGATAAATACTCTAAAATAATTTTTGATGAACTTGCAAAAAATAACTATCTAAAAAACTCCAAAGATC
TAAATCATTTTGCAAAAAATTTAGCAAAATTTATGGGCGAAATCAATGCTTTACACCCTTTTAGAGAAGGTAACGGCAGA
ACTCAAAGAATATTTTTAAACGAGTTGGCTAAAAATGCAGGTTATAAACTTGATTTAAATTTAATTTCTAAGCATAAAAT
GATACATGCTTGTGCAGAAGCTTCACAATTAAAACCTGGAAGATTGGAGGCTTTAATTAAAGACAATCTAAAAAACTTTA
GACAAAATTTAGATTTGGAGCAAAATAAAGGAATATCATTATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT230805 WP_001259255.1 NZ_CP090456:1897243-1897494 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT230805 NZ_CP125385:28365-28607 [Campylobacter jejuni]
ATGCAAAAACAATATCCCGAAGTGCATAGCTTAGAAGAAAGTCTTGCGATACTTAAAAAATATAAAGATGATTTAACTAA
AGAGCAATATGAAGGTATTAAATCTGTTATTTGCGGACACGCTATTGAAGATATGTTTGCAAATGAAAAAGATGTTATCG
ATATGATAAAAATTGCAAAAGATGAAGCAAATGCCGATGAAATAATCGCCGAATATAAAAGAGAATGGGGAGTAAATGAT
TGA
ATGCAAAAACAATATCCCGAAGTGCATAGCTTAGAAGAAAGTCTTGCGATACTTAAAAAATATAAAGATGATTTAACTAA
AGAGCAATATGAAGGTATTAAATCTGTTATTTGCGGACACGCTATTGAAGATATGTTTGCAAATGAAAAAGATGTTATCG
ATATGATAAAAATTGCAAAAGATGAAGCAAATGCCGATGAAATAATCGCCGAATATAAAAGAGAATGGGGAGTAAATGAT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|