Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 51717..52143 | Replicon | plasmid pPT62-106kb |
| Accession | NZ_CP090450 | ||
| Organism | Escherichia coli strain PT62 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | LZ175_RS23170 | Protein ID | WP_001372321.1 |
| Coordinates | 51717..51842 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 51919..52143 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ175_RS23130 (47086) | 47086..47775 | - | 690 | WP_039002187.1 | conjugal transfer transcriptional regulator TraJ | - |
| LZ175_RS23135 (47962) | 47962..48345 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| LZ175_RS23140 (48666) | 48666..49268 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| LZ175_RS23145 (49565) | 49565..50386 | - | 822 | WP_001234469.1 | DUF932 domain-containing protein | - |
| LZ175_RS23150 (50508) | 50508..50795 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| LZ175_RS23155 (50820) | 50820..51026 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| LZ175_RS23160 (51096) | 51096..51269 | + | 174 | Protein_58 | hypothetical protein | - |
| LZ175_RS23165 (51267) | 51267..51497 | - | 231 | WP_001426396.1 | hypothetical protein | - |
| LZ175_RS23170 (51717) | 51717..51842 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| LZ175_RS23175 (51784) | 51784..51933 | - | 150 | Protein_61 | plasmid maintenance protein Mok | - |
| - (51919) | 51919..52143 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (51919) | 51919..52143 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (51919) | 51919..52143 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (51919) | 51919..52143 | - | 225 | NuclAT_0 | - | Antitoxin |
| LZ175_RS23180 (51955) | 51955..52143 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| LZ175_RS23185 (52112) | 52112..52874 | - | 763 | Protein_63 | plasmid SOS inhibition protein A | - |
| LZ175_RS23190 (52871) | 52871..53305 | - | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
| LZ175_RS23195 (53360) | 53360..55318 | - | 1959 | WP_039000998.1 | ParB/RepB/Spo0J family partition protein | - |
| LZ175_RS23200 (55383) | 55383..55616 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| LZ175_RS23205 (55673) | 55673..56212 | - | 540 | WP_032332913.1 | single-stranded DNA-binding protein | - |
| LZ175_RS23210 (56238) | 56238..56444 | - | 207 | WP_000275853.1 | hypothetical protein | - |
| LZ175_RS23215 (56685) | 56685..56912 | - | 228 | WP_071961421.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aph(3')-Ia / mef(B) / sul3 | - | 1..106761 | 106761 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T230793 WP_001372321.1 NZ_CP090450:c51842-51717 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T230793 NZ_CP125365:c4845890-4845135 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGCTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGCTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA
Antitoxin
Download Length: 225 bp
>AT230793 NZ_CP090450:c52143-51919 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
