Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 16409..16663 | Replicon | plasmid pPT62-106kb |
| Accession | NZ_CP090450 | ||
| Organism | Escherichia coli strain PT62 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | LZ175_RS22975 | Protein ID | WP_001312851.1 |
| Coordinates | 16409..16558 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 16602..16663 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ175_RS22940 (11789) | 11789..12204 | - | 416 | Protein_14 | IS1-like element IS1B family transposase | - |
| LZ175_RS22945 (12453) | 12453..12854 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| LZ175_RS22950 (12787) | 12787..13044 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| LZ175_RS22955 (13137) | 13137..13790 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| LZ175_RS22960 (14728) | 14728..15585 | - | 858 | WP_039002220.1 | incFII family plasmid replication initiator RepA | - |
| LZ175_RS22965 (15578) | 15578..15652 | - | 75 | WP_061357229.1 | RepA leader peptide Tap | - |
| LZ175_RS22970 (15884) | 15884..16141 | - | 258 | WP_001541895.1 | replication regulatory protein RepA | - |
| LZ175_RS22975 (16409) | 16409..16558 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (16602) | 16602..16663 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (16602) | 16602..16663 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (16602) | 16602..16663 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (16602) | 16602..16663 | + | 62 | NuclAT_1 | - | Antitoxin |
| LZ175_RS22980 (17005) | 17005..17217 | - | 213 | WP_001541896.1 | ANR family transcriptional regulator | - |
| LZ175_RS22985 (17352) | 17352..17912 | - | 561 | WP_000139310.1 | fertility inhibition protein FinO | - |
| LZ175_RS22990 (17967) | 17967..18710 | - | 744 | WP_039002216.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aph(3')-Ia / mef(B) / sul3 | - | 1..106761 | 106761 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T230789 WP_001312851.1 NZ_CP090450:c16558-16409 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T230789 NZ_CP125365:c176389-176108 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA
Antitoxin
Download Length: 62 bp
>AT230789 NZ_CP090450:16602-16663 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
