Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4237786..4238374 Replicon chromosome
Accession NZ_CP090418
Organism Stenotrophomonas maltophilia strain WGB211

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag LYZ64_RS19740 Protein ID WP_080356578.1
Coordinates 4238096..4238374 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LYZ64_RS19735 Protein ID WP_049463234.1
Coordinates 4237786..4238085 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LYZ64_RS19715 4233199..4234386 + 1188 WP_106469169.1 pyridoxal phosphate-dependent aminotransferase -
LYZ64_RS19720 4234523..4236619 - 2097 WP_164089745.1 prolyl oligopeptidase family serine peptidase -
LYZ64_RS19725 4236689..4237015 - 327 WP_106469171.1 hypothetical protein -
LYZ64_RS19730 4237143..4237745 + 603 WP_094001036.1 lipocalin family protein -
LYZ64_RS19735 4237786..4238085 - 300 WP_049463234.1 HigA family addiction module antitoxin Antitoxin
LYZ64_RS19740 4238096..4238374 - 279 WP_080356578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LYZ64_RS19745 4238623..4239312 - 690 WP_014038544.1 methionine ABC transporter permease -
LYZ64_RS19750 4239309..4240316 - 1008 WP_106469172.1 methionine ABC transporter ATP-binding protein -
LYZ64_RS19755 4240517..4241413 - 897 WP_106469173.1 DMT family transporter -
LYZ64_RS19760 4241630..4242112 + 483 WP_006471121.1 YajQ family cyclic di-GMP-binding protein -
LYZ64_RS19765 4242149..4243243 - 1095 WP_234500106.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10686.18 Da        Isoelectric Point: 9.9466

>T230704 WP_080356578.1 NZ_CP090418:c4238374-4238096 [Stenotrophomonas maltophilia]
MIRSFRCKQTRALFEGTCPRAWLSIRRAAERKLQLLDSAQTLAFLRSPPGNRLEALSGDRRGQYSLRINDQWRLCFTWTD
NGADAVEIVDYH

Download         Length: 279 bp

>T230704 NZ_CP125335:39631-39942 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10916.62 Da        Isoelectric Point: 11.2297

>AT230704 WP_049463234.1 NZ_CP090418:c4238085-4237786 [Stenotrophomonas maltophilia]
MKRPHNGMRAIHPGEILREEFLMPLALSVNALARALDVPATRLHAIVHGERSISADTAARLARHFGGDAASWLAMQAAYD
LKTLPTRSEIERRVQPRAA

Download         Length: 300 bp

>AT230704 NZ_CP125335:39939-40358 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References